SELECTIVE ACTIVATION OF MESOAMYGDALOID DOPAMINE NEURONS BY CONDITIONED STRESS - ATTENUATION BY DIAZEPAM
SELECTIVE ACTIVATION OF MESOAMYGDALOID DOPAMINE NEURONS BY CONDITIONED STRESS - ATTENUATION BY DIAZEPAM
复制标题
DOI：
10.1016/0006-8993(92)91079-t
复制
发表时间：
1992-09-11
期刊：
影响因子：
2.9
通讯作者：
KILTS, CD
中科院分区：
文献类型：
--
作者：
COCO, ML;KUHN, CM;KILTS, CD
大鼠大脑中的多巴胺（DA）神经元群会被压力选择性激活，而抗焦虑药会减弱这种反应。鉴于杏仁核复合体的组成核在条件关联、应激反应和苯二氮卓类药物的抗焦虑作用中的作用，我们假设特定的中杏仁核 DA 预测可能对条件应激和地西泮 (DZ) 的影响特别敏感。我们绘制了条件应激源对不同杏仁核和其他脑核和区域中 DA 代谢物高香草酸 (HVA) 浓度的影响，以及 DZ（1 或 3 mg/kg）对有药物经验的受试者的条件反应的影响。条件应激范式导致经典应激指数显着升高，包括血清皮质酮和血浆肾上腺素。条件应激诱导的 DA 神经元估计活动增加对于投射到中央、基底外侧和外侧杏仁核的 DA 神经元以及投射到背隔核的 DA 神经元具有特异性。条件应激引起的反应性杏仁核 HVA 浓度增加被低剂量的 DZ 抗焦虑作用所拮抗。这些结果表明中杏仁核 DA 预测的一个子集在转换感知压力源对杏仁核复合体输出的影响方面发挥着作用。还提出了特定的杏仁核 DA 投射在条件性恐惧或预期性焦虑的形成中的作用及其通过抗焦虑药的调节。
Populations of dopamine (DA) neurons in the rat brain are selectively activated by stress, and the response is attenuated by the administration of anxiolytics. Given the role of the component nuclei of the amygdaloid complex in conditioned associations, stress responses and the anxiolytic effects of benzodiazepines, we hypothesized that particular mesoamygdaloid DA projections might be especially sensitive to the effects of conditioned stress and to diazepam (DZ). We mapped the effect of a conditioned stressor on the concentration of the DA metabolite homovanillic acid (HVA) in distinct amygdaloid nuclei and other brain nuclei and areas and the effect of DZ (1 or 3 mg/kg) on the conditioned response in drug-experienced subjects. The conditioned stress paradigm resulted in significant elevations in classical indices of stress, including serum corticosterone and plasma epinephrine. Conditioned stress-induced increases in the estimated activity of DA neurons were specific for DA neurons projecting to the central, basolateral and lateral amygdaloid nuclei, and for DA projections to the dorsal septal nucleus. Conditioned stress-induced increases in the HVA concentration of responsive amygdaloid nuclei were antagonized by low, anxiolytic doses of DZ. These results indicate a role for a subset of mesoamygdaloid DA projections in transducing the impact of perceived stressors on the output of the amygdaloid complex. A role for particular amygdaloid DA projections in the formation of conditioned fear or anticipatory anxiety and its modulation by anxiolytics is also suggested.