Natural history of Sin Nombre virus in western Colorado.
Natural history of Sin Nombre virus in western Colorado.
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DOI：
10.3201/eid0501.990115
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发表时间：
1999-01
影响因子：
11.8
通讯作者：
Beaty, B J
中科院分区：
文献类型：
--
作者：
Calisher, C H;Sweeney, W;Mills, J N;Beaty, B J
在科罗拉多西部的啮齿动物种群中对辛诺布尔病毒（SNV）的免疫球蛋白G（IgG）抗体进行的标记-再捕获纵向研究（1994年-结果总结至1997年10月）表明，在两个地点存在SNV或密切相关的汉坦病毒。大多数啮齿类动物（主要是鹿鼠，Peromyscus maniculatus，和pinyon小鼠，P. truei）没有坚持超过1个月后，第一次捕获的诱捕网。有些持续超过1年，这表明即使是少数感染的鹿鼠也可以作为跨季节的水库和越冬病毒维持的机制。两个地点成年动物的伤口和SNV抗体之间的正相关表明，当某些人群中受感染的啮齿动物与未受感染的啮齿动物战斗时，会发生病毒扩增。在这两个地点，雄性啮齿类动物的血清阳性小鼠的百分比大于重新捕获的小鼠，这表明雄性小鼠比雌性小鼠对SNV流行病周期的贡献更大。在鹿鼠中，IgG抗体流行率波动与种群波动呈正相关。鹿鼠的血清转化率主要发生在夏末和仲冬，高于血清阳性率，这表明鹿鼠活得越久，它们感染SNV的可能性就越大。
A mark-recapture longitudinal study of immunoglobulin G (IgG) antibody to Sin Nombre virus (SNV) in rodent populations in western Colorado (1994-results summarized to October 1997) indicates the presence of SNV or a closely related hantavirus at two sites. Most rodents (principally deer mice, Peromyscus maniculatus, and pinyon mice, P. truei) did not persist on the trapping webs much beyond 1 month after first capture. Some persisted more than 1 year, which suggests that even a few infected deer mice could serve as transseasonal reservoirs and mechanisms for over-winter virus maintenance. A positive association between wounds and SNV antibody in adult animals at both sites suggests that when infected rodents in certain populations fight with uninfected rodents, virus amplification occurs. At both sites, male rodents comprised a larger percentage of seropositive mice than recaptured mice, which suggests that male mice contribute more to the SNV epizootic cycle than female mice. In deer mice, IgG antibody prevalence fluctuations were positively associated with population fluctuations. The rates of seroconversion, which in deer mice at both sites occurred mostly during late summer and midwinter, were higher than the seroprevalence, which suggests that the longer deer mice live, the greater the probability they will become infected with SNV.