Cell cycle related proteins as prognostic parameters in radically resected non-small cell lung cancer
Cell cycle related proteins as prognostic parameters in radically resected non-small cell lung cancer
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DOI：
10.1136/jcp.2004.023531
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Caputi, M
中科院分区：
文献类型：
--
作者：
Esposito, V;Baldi, A;Caputi, M
背景资料：实验证据表明，肺癌的发展和进展可能与增加的增殖率有关。目的/方法：评估一系列具有良好特征的非小细胞肺癌（NSCLC）标本中细胞周期机制7种成分的免疫组化表达结果：多变量分析显示，同时失去这些因子中的三种-细胞周期蛋白D1，细胞周期蛋白依赖性激酶抑制剂p16，肿瘤抑制因子视网膜母细胞瘤蛋白Rb 2/ p130 -与生存相关，证实了细胞周期蛋白D1 - p16 -视网膜母细胞瘤肿瘤抑制因子通路在大多数肺癌样本中失活的假设。这些结果表明，细胞周期检查点的失控在肺癌中是常见的，并支持了细胞周期检查点之间的功能合作的想法。不同的细胞周期调节蛋白构成了细胞生长控制和肿瘤抑制中的另一个调节水平。
Background: Experimental evidence suggests that lung cancer development and progression can be linked to an increased proliferation rate.Aims/Methods: To evaluate the immunohistochemical expression of seven components of the cell cycle machinery in a series of well characterised non-small cell lung cancer (NSCLC) specimens ( n = 105).Results: Multivariate analysis revealed that simultaneous loss of expression of three of these factors - cyclin D1, the cyclin dependent kinase inhibitor p16, and the tumour suppressor retinoblastoma protein Rb2/ p130 - correlated with survival, confirming the hypothesis that the cyclin D1 - p16 - retinoblastoma tumour suppressor pathway is inactivated in most lung cancer samples.Conclusions: These results suggest that loss of control of cell cycle checkpoints is a common occurrence in lung cancer and support the idea that functional cooperation between different cell cycle regulatory proteins constitutes another level of regulation in cell growth control and tumour suppression.