Preparation of electrospun poly(lactic acid)-based hybrids containing siloxane-doped vaterite particles for bone regeneration.
Preparation of electrospun poly(lactic acid)-based hybrids containing siloxane-doped vaterite particles for bone regeneration.
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用于骨再生的含有硅氧烷掺杂的球霰石颗粒的电纺聚乳酸基杂化物的制备。
DOI：
10.1163/092050611x582867
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Fujikura K
中科院分区：
文献类型：
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作者：
Fujikura K
硅氧烷/聚（L-乳酸）/球文石杂化（SiPVH）纤维毡不断释放钙离子和离子硅物质，这些物质具有促进骨再生的潜力。为了改善SiPVH纤维毡的机械性能，评估了各种含硅氧烷的球文石（由SiV表示）含量（10-60重量%）对拉伸性能的影响。SiV含量为30 wt%的SiPVH纤维毡显示出最高的拉伸强度，为2.87 ± 0.39 MPa。基于能量耗散机制，失效起始于应力集中点，如纤维表面的孔隙或填料颗粒。在具有20和30重量% SiV的SiPVH纤维毡的情况下，在填料颗粒周围发生应力集中，其中在纤维失效期间，施加的能量直接转化为填料颗粒周围的小体积膨胀。只有当材料含有特定比例的聚合物和填料颗粒时才能应用这种机制;在这项工作中，纤维毡中的填料含量为20和30重量%。为了用骨样磷灰石涂覆纤维表面，将SiPVH纤维毡浸泡在改性的模拟体液（1.5SBF）中。SiV含量大于30wt%的SiPVH纤维毡在浸泡1天后表面形成类骨磷灰石。这些结果表明，含有30重量% SiV的SiPVH纤维毡具有适合骨填充材料的机械性能。
Siloxane/poly(L-lactic acid)/vaterite hybrid (SiPVH) fibremats constantly release calcium ions and ionic silicon species that have the potential to promote bone regeneration. In order to improve the mechanical properties of the SiPVH fibremats, the effect of various silixane-containing vaterite (denoted by SiV) content (10-60 wt%) on tensile properties was assessed. SiPVH fibremats with 30 wt% SiV content showed the highest tensile strength of 2.87 ± 0.39 MPa. Based on the energy-dissipation mechanism, failure initiated at the stress concentration points such as pores on the fibre surfaces or filler particles. In the case of the SiPVH fibremats with 20 and 30 wt% SiV, stress concentration occurred around the filler particles, where the applied energy was directly converted to small volume dilatation around the filler particles during failure of the fibres. This mechanism can be applied only when the material contains the polymer and the filler particles in specific ratios; 20 and 30 wt% filler content in the fibremat in this work. To coat the fibre surfaces with bone-like apatite SiPVH fibremats were soaked in modified simulated body fluid (1.5 SBF). Bone-like apatite formed on the surfaces of SiPVH fibremats with more than 30 wt% of SiV content in 1 day of soaking. These results reveal that the SiPVH fibremats containing 30 wt% SiV have suitable mechanical properties for bone filler materials.