Practicality of hierarchically macro/mesoporous γ-Al2O3 as a promising sorbent in the preparation of low specific activity 99Mo/99mTc generator
Practicality of hierarchically macro/mesoporous γ-Al2O3 as a promising sorbent in the preparation of low specific activity 99Mo/99mTc generator
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DOI：
10.1016/j.apradiso.2021.109986
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发表时间：
2021-10-19
影响因子：
1.6
通讯作者：
Jia, Zimeng
中科院分区：
文献类型：
--
作者：
Wang, Jieru;Gao, Ruiqin;Jia, Zimeng
分层大/介孔γ-Al 2 O3（HMMA）的合成和各种分析技术的特点。结果表明，HMMA具有大孔（约0.45 μ m）和中孔（约10.6nm），比表面积大（约542 m2·g-1）。研究了HMMA对钼和铼的吸附行为。最大静态吸附量可达250 mg Mo/g HMMA。在10 min内可迅速达到吸收平衡。在初始Mo离子浓度为10，000 mg L-1时，确定穿透容量为约200 mg Mo/g HMMA。此外，吸附机理的结果表明，钼离子强烈反应的γ-Al_2O_3表面上的羟基和相邻的Al原子，同时。制备9.15 mCi（339 MBq）Mo-99发生器，并评价其性能超过一周。99 m的回收率可达89%左右，具有良好的放射性核素纯度、放化纯度和化学纯度，可用于核医学应用。HMMA在制备低比活度（LSA）Mo-99/Tc-99 m发生器方面具有潜在的应用前景。
Hierarchically macro-/mesoporous gamma-Al2O3 (HMMA) was synthesized and characterized by various analytical techniques. The results indicated that HMMA possessed macropores (similar to 0.45 mu m) and mesopores (similar to 10.6 nm) with a large surface area (similar to 542 m(2) g(-1)). The absorption behaviors of Mo and Re with HMMA were investigated. The maximum static absorption capacity could reach about 250 mg Mo per g HMMA. The absorption equilibrium can be attained quickly within 10 mins. At initial Mo ions concertation of 10,000 mg L-1, the breakthrough capacity was determined to be around 200 mg Mo per g HMMA. Additional, absorption mechanism results indicated that Mo ions reacts strongly with a hydroxyl on the surface of gamma-Al2O3 and an adjacent Al atom, simultaneously. A 9.15 mCi (339 MBq) Mo-99 generator was prepared and evaluated its performance for over one week. The recovery of Tc-99m could reach about 89% with favorable radionuclidic, radiochemical and chemical purity for nuclear medicine application. HMMA has a potential application prospect for the preparation of low specific activity (LSA) Mo-99/Tc-99m generator.