Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted anti-tumor drug delivery system with sequential release functions.
Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted anti-tumor drug delivery system with sequential release functions.
复制标题
使用 AuCOOH@FA-CS 药物递送系统双负载 miR-218 模拟物和替莫唑胺：有前景的具有顺序释放功能的靶向抗肿瘤药物递送系统
DOI：
10.1186/s13046-015-0216-8
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发表时间：
2015-09-25
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Fan L;Yang Q;Tan J;Qiao Y;Wang Q;He J;Wu H;Zhang Y
背景
具有肿瘤靶向性的双负荷给药系统
序贯释放功能为抗癌药物提供了一个很有前途的平台
送货。在此，我们建立了一种新型的AuCOOH@FACS纳米凝胶体系
联合递送miR-218模拟(作为生物药物)和替莫唑胺(作为化疗药物)。
方法
采用差示扫描量热法和透射电子显微镜对其进行了表征
粒子和纳米凝胶。为了研究协同作用，计算细胞存活率
药物联合给药和纳米凝胶形式的效果。Au的数量
用电感耦合等离子体质谱(ICPMS)测量细胞和肿瘤的摄取，以定量靶向药物
投放功效。测量肿瘤重量和小鼠体重，以研究其对肿瘤的影响。
纳米凝胶系统的靶向抗肿瘤作用。
结果
结果表明，使用AuCOOH@FACS纳米凝胶作为缓释剂
车辆，药物可以靶向输送到肿瘤部位，细胞内
摄取在更大程度上得到增强，显著的抗肿瘤效果成倍增加
与免费给药组相比增加，没有明显的制度
细胞毒性。
结论
该系统为癌症治疗提供了一种有效的方法，并保持了
在未来改善癌症治疗方面的巨大潜力。
Background
Dual loading drug delivery system with tumor targeting efficacy and
sequential release function provides a promising platform for anticancer drug
delivery. Herein, we established a novel AuCOOH@FACS nanogel system for
co-delivery miR-218 mimics (as bio-drug) and Temozolomide(as chemo-drug).
Methods
DLS and TEM were employed to determine the characteristics of
particles and nanogels. The cell viability was calculated for study synergistic
effect of both drugs coadministration and in nanogel forms. The amounts of Au
uptake were measured by ICP-MS in cell and tumors to quantify the targeting drug
delivery efficacy. Tumor weight and mice weight were investigated to study the
targeting antitumor efficacy of nanogel system.
Results
The results revealed that using AuCOOH@FACS nanogel as delivery
vehicles, drugs could be targeting delivery to tumor site, the intracellular
uptake is enhanced to a greater extent, and significant antitumor efficacy is fold
increase compared with free drug administration group, without noticeable system
cytotoxicity.
Conclusions
This system offers an efficient approach to cancer therapy and holds
significant potential to improve the treatment of cancer in the future.