Juvenile hormone is required to couple imaginal disc formation with nutrition in insects
Juvenile hormone is required to couple imaginal disc formation with nutrition in insects
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DOI：
10.1126/science.1123652
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发表时间：
2006-06-02
期刊：
影响因子：
56.9
通讯作者：
Riddiford, LM
中科院分区：
文献类型：
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作者：
Truman, JW;Hiruma, K;Riddiford, LM
在烟草天蛾 Manduca sexta 的饥饿幼虫中，幼虫和成虫组织停止生长，前者是因为它们缺乏营养依赖性信号，而后者是因为受到保幼激素的抑制。如果没有保幼激素，尽管严重饥饿，成虫盘仍会形成并生长。这种激素抑制椎间盘形态发生所需的内在信号传导，并且其作用独立于蜕皮类固醇的作用。饥饿和保幼激素治疗使得椎间盘生长的内在方面和营养依赖性方面得以分离，并表明这两个方面都必须发生在椎间盘形态发生的早期阶段，以确保正常生长，形成典型大小的成虫。
In starved larvae of the tobacco hornworm moth Manduca sexta, larval and imaginal tissues stop growing, the former because they lack nutrient-dependent signals but the latter because of suppression by juvenile hormone. Without juvenile hormone, imaginal discs form and grow despite severe starvation. This hormone inhibits the intrinsic signaling needed for disc morphogenesis and does so independently of ecdysteroid action. Starvation and juvenile hormone treatments allowed the separation of intrinsic and nutrient-dependent aspects of disc growth and showed that both aspects must occur during the early phases of disc morphogenesis to ensure normal growth leading to typical-sized adults.