Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression
Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression
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DOI：
10.1007/s00401-001-0496-2
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发表时间：
2002-05-01
影响因子：
12.7
通讯作者：
Herman, MM
中科院分区：
文献类型：
--
作者：
Damadzic, R;Shuangshoti, S;Herman, MM
关于阿尔茨海默病(AD)和精神障碍之间的联系，早期的报告提供了相互矛盾的结果。利用40例中年人脑的尸检资料，对9例精神分裂症患者、8例双相情感障碍患者、12例抑郁症患者和11例年龄、性别相匹配的对照组的嗅内皮质、下丘脑和吻侧海马区的神经原纤维缠结和老年斑进行了定量分析。四组间差异无统计学意义。我们的研究表明，阿尔茨海默病类型的变化，可能与AD在晚年发展的可能性有关，在患有精神疾病的中年受试者中没有增加。这一结果也支持了最近的报道，即精神疾病患者的AD发病率没有增加。
Earlier reports have provided conflicting results regarding the association between Alzheimer's disease (AD) and mental disorders. Using a well-characterized postmortem series of 40 middle-aged human brains, we have performed quantitative analysis of neurofibrillary tangles and senile plaques in the entorhinal cortex, subiculum and rostral hippocampus in 9 subjects with schizophrenia, 8 with bipolar disorder, 12 with depression, and 11 age- and sex-matched controls. No significant differences were found among the four groups. Our study indicates that the Alzheimer-type changes, which might be related to the likelihood of AD development later in life, are not increased in middle-aged subjects with mental illness. The result also supports the more recent reports that have demonstrated no increased incidence of AD in mentally ill patients.