Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts
Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts
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DOI：
10.1046/j.1365-3083.2001.00844.x
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发表时间：
2001-01-01
影响因子：
3.7
通讯作者：
Britton, S
中科院分区：
文献类型：
--
作者：
Olobo, JO;Geletu, M;Britton, S
肿瘤坏死因子（TNF）-Alpha的水平，转化生长因子（TGF）-Beta和白介素（IL）-10 -10在肺结核（TB）患者（TB）患者的血浆中，健康接触和血浆和血浆和皮拉神经液的患者患有结节性胸膜炎患者由酶免疫测定检查。在健康的接触中，血浆TNF-α和IL-10的水平升高到显着水平，在TB患者和健康接触的血浆中还检测到高水平的TGF-β和IL-10。胸腔液含有所有三种细胞因子，IL-10水平最高，其次是TGF-beta和TNF-Alpha。结核性胸膜炎患者的血浆还具有三种细胞因子的可检测水平。接触的血浆中TNF-Alpha水平升高，在某种程度上，胸膜炎患者的胸膜液体可能会限制感染，而TB患者血浆中的IL-10升高，接触和胸膜液可能会调节过量的脑膜炎。结核病患者的TGF-β升高表明其在免疫发作中的作用。
Levels of tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta, and interleukin (IL)-10 in plasma of pulmonary tuberculosis (TB) patients and healthy contacts and plasma and pleural fluid of patients with tuberculous pleuritis were examined by enzyme immunoassay. Plasma TNF-alpha and IL-10 were elevated to significant levels in healthy contacts, High levels of TGF-beta and IL-10 were also detected in plasma from TB patients and healthy contacts. Pleural fluid contained all three cytokines with the level of IL-10 being highest followed by TGF-beta and TNF-alpha. Plasma of tuberculous pleuritis patients also had detectable levels of the three cytokines. Increased levels of TNF-alpha in plasma of contacts and to some extent pleural fluid of pleuritis patients, is perhaps to limit the infection, while elevated IL-10 in plasma of TB patients and contacts and pleural fluid would perhaps modulate excess proinflammation. Elevated TGF-beta in TB patients suggests its role in the immunopathogenesis.