Circulating Myeloid Regulatory Cells: Promising Biomarkers in B-Cell Lymphomas.
Circulating Myeloid Regulatory Cells: Promising Biomarkers in B-Cell Lymphomas.
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DOI：
10.3389/fimmu.2020.623993
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发表时间：
2020
影响因子：
7.3
通讯作者：
Roussel M
中科院分区：
文献类型：
--
作者：
Ferrant J;Lhomme F;Le Gallou S;Irish JM;Roussel M
单核细胞/巨噬细胞谱系已显示参与促进肿瘤前肿瘤微环境和B细胞淋巴瘤对治疗的抗性。然而，它在单细胞水平上的描述仍然很差，组织样本也不容易获得。因此，需要对不同B淋巴瘤中的循环髓样细胞区室进行详细分析，以更好地了解治疗耐药的机制并识别风险患者。在这个角度来看，我们审查目前的知识，在B细胞淋巴瘤的循环单核细胞谱系的表型和功能的描述，并提供第一次洞察到这些细胞群体的异质性，在健康和淋巴瘤，使用大规模细胞计数。事实上，单核细胞区室是一个连续体，而不是不同的亚群，如我们的高分辨率方法所证明的，解释了有时令人困惑和矛盾的结论，对不同的群体，包括单核细胞和单核细胞髓源性抑制细胞（M-MDSC）的预后影响。通过在包括有限数量样本的概念验证初步研究中将S100 A9 high单核细胞鉴定为弥漫性大B细胞淋巴瘤（DLBCL）的潜在生物标志物，我们强调了循环髓样调节细胞作为B细胞淋巴瘤诊断和预后生物标志物的潜力。
The monocyte/macrophage lineage has been shown to be involved in the promotion of a protumoral tumor microenvironment and resistance to treatment in B cell lymphomas. However, it is still poorly described at the single cell level, and tissue samples are not easily accessible. Thus, a detailed analysis of the circulating myeloid cell compartment in the different B lymphomas is needed to better understand the mechanisms of resistance to treatment and identify at risk patients. In this Perspective, we review current knowledge on the phenotypic and functional description of the circulating monocytic lineage in B cell lymphomas and provide first insights into the heterogeneity of these cell populations in health and lymphoma, using mass cytometry. Indeed, the monocytic compartment is a continuum more than distinct subpopulations, as demonstrated by our high-resolution approach, explaining the sometimes confusing and contradictory conclusions on the prognostic impact of the different populations, including monocytes and monocytic myeloid derived suppressor cells (M-MDSC). By identifying S100A9high monocytic cells as a potential biomarker in diffuse large B cell lymphoma (DLBCL) in this proof-of-concept preliminary study including a limited number of samples, we underline the potential of circulating myeloid regulatory cells as diagnostic and prognostic biomarkers in B-cell lymphomas.
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影响因子：
10.1
作者：
Gabrilovich DI
通讯作者：
Gabrilovich DI
影响因子：
20.3
作者：
Jitschin, Regina;Braun, Martina;Mougiakakos, Dimitrios
通讯作者：
Mougiakakos, Dimitrios
DOI：
10.1126/science.1198704
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bendall SC;Simonds EF;Qiu P;Amir el-AD;Krutzik PO;Finck R;Bruggner RV;Melamed R;Trejo A;Ornatsky OI;Balderas RS;Plevritis SK;Sachs K;Pe'er D;Tanner SD;Nolan GP
通讯作者：
Nolan GP
影响因子：
11.4
作者：
Hanna, B. S.;McClanahan, F.;Seiffert, M.
通讯作者：
Seiffert, M.
影响因子：
3.8
作者：
Charbonneau, Bridget;Maurer, Matthew J.;Ansell, Stephen M.;Slager, Susan L.;Fredericksen, Zachary S.;Ziesmer, Steven C.;Macon, William R.;Habermann, Thomas M.;Witzig, Thomas E.;Link, Brian K.;Cerhan, James R.;Novak, Anne J.
通讯作者：
Novak, Anne J.