Epidemiology of Seasonal Coronaviruses: Establishing the Context for the Emergence of Coronavirus Disease 2019
Epidemiology of Seasonal Coronaviruses: Establishing the Context for the Emergence of Coronavirus Disease 2019
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DOI：
10.1093/infdis/jiaa185
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发表时间：
2020-07-01
影响因子：
6.4
通讯作者：
Murcia, Pablo R.
中科院分区：
文献类型：
--
作者：
Nickbakhsh, Sema;Ho, Antonia;Murcia, Pablo R.
在缺乏特定环境流行病学数据的情况下，2019年冠状病毒病（COVID-19）的公共卫生准备工作具有挑战性。本文描述了英国苏格兰西部季节性冠状病毒（scov）和其他共循环病毒的流行病学。我们分析了2005年至2017年期间对多种呼吸道病毒进行分子检测的bb70000例呼吸道疾病的常规诊断数据。CoV-229E、CoV-OC43和CoV-NL63与患者年龄和性别的统计相关性存在差异。此外，sCoV暴发的时间和规模没有同时发生，也没有合并感染的报告。对于其他共循环呼吸道病毒，我们发现了与scov积极而非消极相互作用的证据。这些发现强调了在COVID-19鉴别诊断中考虑共循环病毒的重要性。需要进一步的工作来确定scov之间和与COVID-19之间的交叉保护性免疫的发生/程度，以及病毒合并感染在COVID-19疾病严重程度中的作用。
Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age and sex differed between CoV-229E, CoV-OC43, and CoV-NL63. Furthermore, the timing and magnitude of sCoV outbreaks did not occur concurrently, and coinfections were not reported. With respect to other cocirculating respiratory viruses, we found evidence of positive, rather than negative, interactions with sCoVs. These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. Further work is needed to establish the occurrence/degree of cross-protective immunity conferred across sCoVs and with COVID19, as well as the role of viral coinfection in COVID-19 disease severity.