EFFECTS OF BAY 1-5240, A FIXED COMBINATION OF LOW-DOSE NIFEDIPINE AND ACEBUTOLOL ON HYPERTENSION - COMPARISON WITH STANDARD DOSE NIFEDIPINE
EFFECTS OF BAY 1-5240, A FIXED COMBINATION OF LOW-DOSE NIFEDIPINE AND ACEBUTOLOL ON HYPERTENSION - COMPARISON WITH STANDARD DOSE NIFEDIPINE
复制标题
DOI：
10.1007/bf00635702
复制
发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
SCHREIBER, U
中科院分区：
文献类型：
--
作者：
LEJEUNE, P;GUNSELMANN, W;SCHREIBER, U
来自 4 个诊所的患者 (116) 参与了一项双盲研究，以评估 (BAY 1 5240)（一种硝苯地平-醋丁洛尔固定组合（10 mg + 100 mg））与硝苯地平 20 mg 对原发性高血压的疗效进行比较。在为期10周的研究中，治疗后1至3小时，BAY 15240组的平均卧位血压从175.5/105.2毫米汞柱下降至148.3/88.0毫米汞柱，硝苯地平组从174.3/102.9毫米汞柱下降至150.3/86.5毫米汞柱。结果还显示，治疗前（最后一片药后 24 小时）以及服用任一药物 4 周后体力消耗后的平均收缩压 (SBP) 和舒张压 (DBP) 均出现可比下降。额外 4 周加倍剂量可产生中度且类似的血压额外降低。结果表明用低剂量的β-肾上腺素能阻断剂与10mg硝苯地平组合治疗原发性高血压的可能性。两种治疗方案均具有良好的耐受性。 BAY15240组中的1名患者和硝苯地平组中的2名患者均由同一研究者治疗，但因硝苯地平前期头痛而退出研究。
Patients (116) from 4 clinics participated in a double blind study to assess the efficacy of (BAY 1 5240), a nifedipine-acebutolol fixed combination (10 mg + 100 mg), as compared to nifedipine 20 mg in essential hypertension. During the 10 wk study, the mean recumbent blood pressure decreased 1 to 3 h after treatment from 175.5/105.2 to 148.3/88.0 mm Hg in the BAY 15240 group and from 174.3/102.9 to 150.3/86.5 mm Hg in the nifedipine group. The results also showed a comparable decrease in the mean systolic (SBP) and diastolic (DBP) blood pressures before treatment (24 h after last tablet) and after physical exertion before and after either drug after either drug given for 4 wk. Doubling of the dose for 4 additional wk produced a moderate and similar additional decrease in blood presusre. The results show the possibility of treating essential hypertension with a low dose of a .beta.-adrenergic blocking agent in combination with 10 mg nifedipine. Both regimens were well tolerated. One patient in the BAY15240 group and 2 in the nifedipine group, all treated by the same investigator, were withdrawn from the study because of headache during the nifedipine pre-period.