Elevated daytime cortisol levels: A biomarker of subsequent major affective disorder?
Elevated daytime cortisol levels: A biomarker of subsequent major affective disorder?
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DOI：
10.1016/j.jad.2011.01.007
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发表时间：
2011-07-01
影响因子：
6.6
通讯作者：
Ostiguy, Caroline S.
中科院分区：
文献类型：
--
作者：
Ellenbogen, Mark A.;Hodgins, Sheilagh;Ostiguy, Caroline S.
背景：一些研究报道，父母患有情感障碍的后代白天分泌高水平的皮质醇。一些研究表明，高皮质醇水平先于情感症状的发作。迄今为止，只有一项研究发现，皮质醇的升高先于情感障碍的发作，但这仅在携带5-羟色胺转运蛋白基因启动子多态性的短等位基因的青年中观察到（Goodyer埃塔尔，方法：我们随访了28名双相情感障碍父母的后代和31名无情感障碍父母的后代，从平均年龄17.5岁到平均年龄20.0岁，以确定基线皮质醇水平是否预测了随后的情感障碍发展。在基线和随访时，参与者完成了诊断评估，并在基线时提供了唾液样本。结果：在59名参与者中，平均年龄为17.5岁的皮质醇水平预测了随后2.5年内情感障碍的发展（优势比：2.1，95%可信区间= 1.0-4.1，p < 0.05），在第一次评估时控制了后代的精神障碍，并且父母中有一方患有双相情感障碍。研究结果应谨慎解释，因为样本量small.Conclusion：在青春期后期白天皮质醇水平升高可能是情感障碍的脆弱性的生物标志物。(C)2011 Elsevier B. V.保留所有权利。
Background: Several studies have reported that the offspring of parents with affective disorders secrete high levels of daytime cortisol. A few studies have shown that high cortisol levels preceded the onset of affective symptoms. Only one study to date has found that an elevation in cortisol preceded the onset of an affective disorder, but this was observed only in those youth carrying the short allele of the serotonin transporter gene promoter polymorphism (Goodyer etal., 2009).Methods: We followed 28 offspring of parents with bipolar disorder and 31 offspring of parents with no affective disorder from an average age of 17.5 years to an average age of 20.0 years to determine if cortisol levels at baseline predicted the subsequent development of an affective disorder. At baseline and at follow-up participants completed a diagnostic assessment, and at baseline they provided saliva samples. Daytime cortisol levels were computed as the mean of eight to 24 samples measured across two to six days.Results: Among the 59 participants, cortisol levels at the mean age of 17.5 years predicted the development of an affective disorder during the subsequent 2.5 year (odds ratio: 2.1, 95% confidence interval = 1.0-4.1, p < 0.05) after controlling for offspring mental disorders at the first assessment and having a parent with bipolar disorder.Limitations: The findings should be interpreted with caution, as the sample size was small.Conclusion: Elevated daytime cortisol levels in late adolescence may be a biomarker of vulnerability for affective disorders. (C) 2011 Elsevier B.V. All rights reserved.