Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis
Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis
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DOI：
10.4161/epi.6.7.16314
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发表时间：
2011-07-01
期刊：
影响因子：
3.7
通讯作者：
Chen, Hong
中科院分区：
文献类型：
--
作者：
Li, Qian;Chen, Hong
结肠和直肠癌（结直肠癌，CRC）是世界上第三大常见癌症。CRC死亡占所有癌症死亡的8%左右，使其成为癌症死亡的第四大常见原因。结肠癌的高死亡率主要归因于其转移。已经努力鉴定转移抑制基因，其编码负责抑制转移但不抑制原发性肿瘤生长的蛋白质。对转移抑制基因的研究表明，表观遗传修饰（如DNA启动子甲基化和组蛋白修饰）对许多转移抑制基因的表达起着至关重要的调节作用，表明表观遗传异常改变与肿瘤转移之间存在联系。本文就近年来在大肠癌转移中受表观遗传修饰，特别是DNA甲基化和组蛋白修饰调控的转移抑制因子的研究进展作一综述。此外，我们还将讨论大豆异黄酮抑制结直肠癌转移的最新进展，重点是表观遗传机制。
Colon and rectal cancer (colorectal cancer, CRC) is the third most common cancer worldwide. Deaths from CRC account for around 8% of all cancer deaths, making it the fourth most common cause of death from cancer. The high mortality rate of colon cancer is mainly attributable to its metastasis. Efforts have been made to identify metastasis suppressor genes, which encode proteins responsible for inhibiting the metastasis but not suppressing the growth of primary tumors. Studies on metastasis suppressor genes demonstrated that epigenetic modifications, such as DNA promoter methylation and histone modification, play crucial roles in regulating the expression of many metastasis suppressor genes, which indicates the association between aberrant epigenetic alterations and cancer metastasis. This review will focus on the recent findings regarding metastasis suppressors regulated by epigenetic modifications, particularly DNA methylation and histone modification, in CRC metastasis. Also, we will discuss recent progress on the suppression of CRC metastasis by genistein, a soy isoflavone, with a focus on epigenetic mechanisms.