In vivo effects of methamphetamine on HIV-1 replication: A population-based study
In vivo effects of methamphetamine on HIV-1 replication: A population-based study
复制标题
甲基苯丙胺对 HIV-1 复制的体内影响：一项基于人群的研究
DOI：
10.1016/j.drugalcdep.2015.12.027
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Liang, Hao
中科院分区：
文献类型：
--
作者：
Jiang, Junjun;Wang, Minlian;Liang, Hao
工作背景：虽然一些体外研究表明，甲基苯丙胺（METH）可以增加HIV-1在人体免疫细胞中的复制，甲基苯丙胺的使用和HIV-1的发病机制之间的直接联系仍有待确定之间的HIV-1 patients.Methods：根据甲基苯丙胺的使用和HIV-1感染的状态，我们招募参与者，并将他们分为四组：甲基苯丙胺+HIV+，甲基苯丙胺HIV+，甲基苯丙胺+HIV-，和METH-HIV-。结果：共60名受试者入组本研究，每组15人。METH+HIV+组HIV病毒载量明显高于METH HIV+组，而CD 4 + T细胞计数在两组之间呈相反趋势（p
Background: Although a number of in vitro studies have shown that methamphetamine (METH) can increase HIV-1 replication in human immune cells, a direct link between METH use and HIV-1 pathogenesis remains to be determined among HIV-1 patients.Methods: According to the status of METH use and HIV-1 infection, we enrolled participants and divided them into four groups: METH+HIV+, METH HIV+, METH+HIV-, and METH-HIV-. HIV viral loads and HIV-1-related cellular factors were measured and compared among different groups.Results: A total of 60 participants were enrolled into this study, 15 within each group. HIV viral loads in METH+HIV+ group were significantly higher than those in METH HIV+ group, while CD4+ T cell counts had an inverse trend between the two groups (p