How to design 13C para-hydrogen-induced polarization experiments for MRI applications.
How to design 13C para-hydrogen-induced polarization experiments for MRI applications.
复制标题
如何为 MRI 应用设计 13C 仲氢诱导极化实验。
DOI：
10.1002/cmmi.407
复制
发表时间：
2011
影响因子：
--
通讯作者：
S. Aime
中科院分区：
文献类型：
--
作者：
F. Reineri;Alessandra Viale;W. Dastrù;R. Gobetto;S. Aime
超极化技术在核磁共振成像中的应用越来越受到人们的关注，特别是对于~(13)C或~(129)Xe等原子核。在提出的不同方法中，仲氢诱导极化需要相对便宜的设备。利用仲氢建立核磁共振实验需要应用来自不同知识领域的技能和方法。文中介绍了该方法的基本理论和实际应用情况。含膦络合物的Rh(I)络合物催化的具有标记的(13)CO基团邻近三键的炔烃的对氢反应是产生和保持高异核极化效应的最佳选择。为了将反相极化转换为同相(净)(13)C极化用于磁共振成像，有必要建立所描述的磁场循环程序。已经使用快速成像序列(REARE和TRUE FISP)获得了体外和体内图像。
The application of hyperpolarization techniques for MRI purposes is gathering increasing attention, especially for nuclei such as (13)C or (129)Xe. Among the different proposed methods, ParaHydrogen Induced Polarization requires relatively cheap equipment. The setup of an MRI experiment by means of parahydrogen requires the application of skills and methodologies that derive from different fields of knowledge. The basic theory and a practical insight of this method are presented here. Parahydrogenation of alkynes, having a labelled (13)CO group adjacent to the triple bond, catalyzed by Rh(I) complexes containing a chelating phosphine, represents the best choice for producing and maintaining high heteronuclear polarization effect. In order to transform anti-phase into in-phase (net) (13)C polarization for MRI application it is necessary to set up the described magnetic field cycle procedure. In vitro and in vivo images have been acquired using fast imaging sequences (RARE and trueFISP).