Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma.
Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma.
复制标题
人胎儿血浆中低密度脂蛋白胆固醇与硫酸脱氢异雄酮之间的反比关系。
作者：
C. Parker;E. Simpson;D. Bilheimer;K. Leveno;B. Carr;P. Macdonald
一个显着的负相关关系被发现在脐带血浆中的硫酸脱氢异雄酮和低密度脂蛋白（LDL）-胆固醇，但不是高密度脂蛋白-胆固醇或极低密度脂蛋白-胆固醇的浓度之间。硫酸脱氢异雄酮是人胎儿肾上腺的主要分泌产物，也是胎盘雌激素产生的主要前体。这些数据表明，胎儿血浆中LDL-胆固醇的浓度受胎儿肾上腺利用LDL-胆固醇生成类固醇的速率的影响，不一定与高胆固醇血症或其他脂蛋白疾病的遗传易感性相关。
A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.