Alterations of cell signaling pathways in pancreatic cancer
Alterations of cell signaling pathways in pancreatic cancer
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DOI：
10.2741/1388
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Zhao, SJ
中科院分区：
文献类型：
--
作者：
Freeman, JW;DeArmond, D;Zhao, SJ
胰腺导管腺癌仍然是所有成人恶性肿瘤中预后最差的，5年生存率不到4%。提高胰腺癌患者生存率的一种方法是确定有助于胰腺癌侵袭性致病性的新生物学靶点，并开发能够干扰这些靶点功能的试剂。除了确定胰腺癌的遗传谱外，许多研究都集中在异常细胞信号通路及其在胰腺癌生物学和治疗反应中的作用。本综述虽然不全面，但将讨论其中几种途径的显著特征。这些包括tgfβ信号在肿瘤抑制和肿瘤促进中的作用，以及在胰腺癌中解除磷酸酪氨酸激酶受体信号通路的影响。
Pancreatic ductal adenocarcinomas continue to have the worst prognosis of any adult malignancy with a five-year survival rate of less than 4%. One approach to improve patient survival from pancreatic cancer is to identify new biological targets that contribute to the aggressive pathogenecity of this disease and to develop reagents that will interfere with the function of these targets. Apart from the identification of the genetic profile of pancreatic cancer, a number of studies have focused on aberrant cell signaling pathways and their role in pancreatic cancer biology and response to therapy. This review, although not comprehensive, will discuss the salient features of several of these pathways. These include the roles of TGFbeta signaling in both tumor suppression and tumor promotion and the effects of deregulation of phosphotyrosine kinase receptor signaling pathways in pancreatic cancer.