Radiation-induced crosslinking of collagen gelatin into a stable hydrogel
Radiation-induced crosslinking of collagen gelatin into a stable hydrogel
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DOI：
10.1007/s10967-007-7003-8
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发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Angelini, G.
中科院分区：
文献类型：
--
作者：
Cataldo, F.;Ursini, O.;Angelini, G.
明胶是从猪皮中提取的低分子量胶原蛋白衍生物，经γ射线辐照后可转化为稳定的永久性水凝胶。在室温下，在不存在空气的情况下，以2.2 kGy/h的剂量率，以12、25、50、100、150、200 kGy的剂量辐照含有3%明胶水溶液的一系列样品。在低剂量下，获得掺入所有可用水的明胶水凝胶。在高于50 kGy的较高剂量下，明胶水凝胶样品显示出奇怪的收缩现象，这是由于实现了相对高的交联密度水平，因此部分可用的水从凝胶笼中挤出。通过质量分级分析、分光光度分析和旋光分析研究明胶水凝胶样品。通过FT-IR光谱和通过辐射后干燥明胶样品的热分析（DSC、DTA和TGA）与参考未处理样品进行比较来进行进一步表征。
Gelatin, the low molecular weight collagen derivative from porcine skin was transformed into a stable permanent hydrogel by gamma-radiation. A series of samples with 3% gelatin solution in water were irradiated at doses of 12, 25, 50, 100, 150, 200 kGy at room temperature in the absence of air with a dose rate of 2.2 kGy/h. At low dose gelatin hydrogels incorporating all the available water were obtained. At higher doses above 50 kGy, the gelatin hydrogel samples show a curious shrinking phenomenon due to the relatively high crosslinking density level achieved, so part of the available water is squeezed out from the gel cage. The gelatin hydrogel samples were studied by mass fractionation analysis, by spectrophotometric and polarimetric analysis. Further characterization was made by FT-IR spectroscopy and by thermal analysis (DSC, DTA and TGA) of the dried gelatin samples after irradiation in comparison to a reference untreated sample.