Antimicrobial susceptibility and pneumococcal serotypes
Antimicrobial susceptibility and pneumococcal serotypes
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DOI：
10.1093/jac/dkf509
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发表时间：
2002-12-01
影响因子：
5.2
通讯作者：
Casal, J
中科院分区：
文献类型：
--
作者：
Fenoll, A;Asensio, G;Casal, J
抗生素耐药性的增加和血清型流行率的可能变化作为一种新的结合疫苗的结果，有助于重新关注肺炎球菌血清型及其抗生素耐药性的研究。西班牙仍然是青霉素耐药率最高的国家之一，但在过去4-5年中观察到略有下降。耐药性水平也没有增加，研究的11165株分离株中有12.7%表现出高水平的青霉素耐药性，但其中94%的MIC仅为2 mg/L。血清型6、9、14、19和23包括83%的青霉素耐药肺炎球菌，其余17%属于18种不同的血清型。我们分析了这些次要的青霉素耐药血清型，鉴于其潜在的增加后，可能的儿童疫苗接种计划。这些血清型中的四种（11、15、21和35）是最流行的，其中血清型15特别常见，其菌株的耐药率>50%。对这些次要青霉素耐药血清型的有效控制应基于对肺炎球菌流行病学的持续监测。
The increase in antibiotic resistance and the possible changes in serotype prevalence as a consequence of a new conjugated vaccine have contributed to renewed interest in the study of pneumococcal serotypes and their antibiotic resistances. Spain still has one of the highest penicillin resistance rates, but in the past 4-5 years a slight decrease has been observed. The level of resistance has not increased either, 12.7% of the 11165 isolates studied showed high-level penicillin resistance but 94% of these had an MIC of only 2 mg/L. Serotypes 6,9,14,19 and 23 included 83% of the penicillin-resistant pneumococci; the remaining 17% belonged to 18 different serotypes. We analysed these minor penicillin-resistant serotypes in view of their potential increase following a possible child vaccination programme. Four of these serotypes (11, 15, 21 and 35) were the most prevalent, and among them serotype 15 was particularly frequent with >50% of its strains resistant. The effective control of these minor penicillin-resistant serotypes should be based on continuous surveillance of pneumococcal epidemiology.