Neuroimaging studies of mood disorder effects on the brain
Neuroimaging studies of mood disorder effects on the brain
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DOI：
10.1016/s0006-3223(03)00347-0
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发表时间：
2003-08-01
影响因子：
10.6
通讯作者：
Sheline, YI
中科院分区：
文献类型：
--
作者：
Sheline, YI
对早发性复发性抑郁症、与神经系统疾病相关的晚年抑郁症和双相情感障碍的研究揭示了神经解剖回路内的大脑结构变化。该回路最初由 Nauta (1972) 描述，被称为边缘-皮质-纹状体-苍白球-丘脑束，由广泛互连的结构组成。在情感疾病的三维磁共振成像研究中，发现构成该束的许多结构存在体积损失或结构异常。提出解释抑郁症体积损失的机制包括糖皮质激素神经毒性、脑源性生长因子减少、神经发生减少和可塑性丧失。 (C) 2003 年生物精神病学协会。
Studies of early-onset recurrent depression, late life depression associated with neurologic disorders, and bipolar illness have revealed structural brain changes within a neuroanatomical circuit. This circuit, originally described by Nauta (1972), has been termed the limbic-cortical-striatal-pallidal-thalamic tract and is comprised of structures which are extensively interconnected. In three-dimensional magnetic resonance imaging studies of affective illness, many of the structures that comprise this tract have been found to have volume loss or structural abnormalities. Mechanisms proposed to explain volume loss in depression include glucocorticoid neurotoxicity, decreased brain-derived growth factor, decreased neurogenesis, and loss of plasticity. (C) 2003 Society of Biological Psychiatry.