IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures
IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures
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DOI：
10.1007/s00251-001-0408-6
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发表时间：
2002-02-01
期刊：
影响因子：
3.2
通讯作者：
Lefranc, MP
中科院分区：
文献类型：
--
作者：
Ruiz, M;Lefranc, MP
在IMGT （international ImMunoGencTics database）信息系统（http://irngt.cines .fr）中开发并实现了一个新的数据库IMGT/3Dstructure-DB，以提供免疫球蛋白和t细胞受体结构数据的独特专业资源。使用IMGT工具对相应的蛋白质序列进行注释，可以精确识别这些蛋白质中表达的基因，并根据IMGT标准化命名法和lMGT唯一编号描述框架和互补性决定区域。v域的二维图形表示，被指定为Colliers de Perles，自动生成。查询Web界面允许交互式搜索IMGT/ 3D结构数据库数据。本文介绍了蛋白质数据库中已知三维结构的人类免疫球蛋白的IMGT基因鉴定和Colliers de Perles。
A new database, IMGT/3Dstructure-DB, was developed and implemented in the IMGT (international ImMunoGencTics database) information system (http:// irngt.cines.fr) to provide a unique expertised resource on immunoglobulin and T-cell receptor structural data. Corresponding protein sequences were annotated with IMGT tools, which allow the precise identification of the genes expressed in these proteins, and the description of framework and complementarity determining regions according to the IMGT standardized nomenclature and lMGT unique numbering. Two-dimensional graphical representations of the V-DOMAINs, designated as Colliers de Perles, are automatically produced. A query Web interface allows interactive search of the IMGT/ 3D structure-DB data. In this article, IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures in the Protein Data Bank are presented.