A spectrum of pharmacological activity in some biologically active peptides.
A spectrum of pharmacological activity in some biologically active peptides.
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一些生物活性肽的一系列药理活性。
DOI：
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发表时间：
1962
期刊：
影响因子：
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通讯作者：
G. P. Lewis
中科院分区：
文献类型：
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作者：
G. Bisset;G. P. Lewis
缓激肽、血管紧张素、催产素、加压素和P物质的作用在离体平滑肌制备物和体内都进行了研究。结果发现，大鼠离体子宫和豚鼠回肠可用于区分催产素和缓激肽，大鼠离体结肠和母鸡离体直肠盲肠几乎是P物质的特异性供试品。所有肽对外周血管都有活性，缓激肽、P物质和催产素引起血管舒张，加压素和血管紧张素引起血管收缩;缓激肽、P物质和血管紧张素也引起豚鼠毛细血管通透性增加。只有缓激肽和P物质在低浓度时产生疼痛时，适用于暴露的水泡基地。这两种肽在引起支气管收缩方面也是有活性的。催产素和加压素是唯一具有排乳或抗利尿活性的肽，其可以与心血管效应分离。由这些肽显示的活性谱与已经为加压素和催产素建立的那些功能一致，并且与为缓激肽和血管紧张素建议但尚未完全接受的那些功能一致。它还表明了基于其血管和渗透性效应的P物质的可能功能。
The actions of bradykinin, angiotensin, oxytocin, vasopressin and substance P have been examined both on isolated smooth muscle preparations and in vivo. It was found that the isolated rat uterus and guinea-pig ileum can be used to distinguish between oxytocin and bradykinin and that the isolated rat colon and hen rectal caecum are almost specific test preparations for substance P. All the peptides were active on peripheral blood vessels, bradykinin, substance P and oxytocin causing vasodilatation and vasopressin and angiotensin vasoconstriction; bradykinin, substance P and angiotensin also caused an increase in capillary permeability in guinea-pigs. Only bradykinin and substance P were active in low concentrations in producing pain when applied to an exposed blister base. These two peptides were also active in causing bronchoconstriction. Oxytocin and vasopressin were the only peptides having milk-ejecting or antidiuretic activity which could be dissociated from cardiovascular effects. The spectrum of activity displayed by these peptides is in agreement with those functions which have been established for vasopressin and oxytocin and with those suggested, but not yet fully accepted, for bradykinin and angiotensin. It also indicates a possible function for substance P based on its vascular and permeability effects.