Sex steroid hormone regulation of IgA and IgG in rat uterine secretions
Sex steroid hormone regulation of IgA and IgG in rat uterine secretions
复制标题
性类固醇激素对大鼠子宫分泌物中IgA和IgG的调节
作者：
C. Wira;C. Sandoe
性甾体激素可能在调节全身和分泌性体液免疫系统中起重要作用，在此基础上，我们进行了一系列实验，以阐明性激素对大鼠子宫免疫系统的作用。我们在这里报告，动情周期的阶段和管理的生理量的雌二醇去势大鼠显着影响子宫分泌物中的免疫球蛋白A（伊加）和G（IgG）的积累。IgG在发情前期最高，但在发情期、间情期和卵巢切除术后几乎检测不到。伊加在发情前期最高，在发情期保持升高，但在间情期和卵巢切除术后降至低水平。在测试的类固醇中，只有雌二醇刺激伊加和IgG的出现。这些结果表明，雌二醇是重要的影响存在的两种免疫球蛋白在子宫。
SEX steroid hormones may be important in regulating both the systemic and secretory humoral immune system and on the basis of this hypothesis, we have carried out a series of experiments to clarify the action of the sex hormones on the rat uterine immune system. We report here that the stage of the oestrous cycle and the administration of physiological amounts of oestradiol to castrate rats markedly influences the accumulation of immunoglobulin A (IgA) and G (IgG) in uterine secretions. IgG is maximal at pro-oestrus but barely detectable at oestrus, dioestrus, and following ovariectomy. IgA is highest at pro-oestrus, remains elevated at oestrus, but drops to low levels at dioestrus and following ovariectomy. Of the steroids tested only oestradiol stimulated the appearance of IgA and IgG. These findings indicate that oestradiol is important in influencing the presence of both immunoglobulins in the uterus.