A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
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DOI：
10.1006/bbrc.1999.0252
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发表时间：
1999-03-24
影响因子：
3.1
通讯作者：
Suda, T
中科院分区：
文献类型：
--
作者：
Takahashi, N;Udagawa, N;Suda, T
破骨细胞是一种吸收骨的多核巨细胞，由单核-巨噬细胞谱系细胞发育而来。成骨细胞或骨髓基质细胞参与破骨细胞的骨吸收，肿瘤坏死因子（tumor necrosis factor，TNF）受体-配体家族新成员的发现阐明了成骨细胞/基质细胞调控破骨细胞分化和功能的确切机制。成骨细胞/基质细胞表达TNF-配体家族的新成员“破骨细胞分化因子（ODF）/骨保护素配体（OPGL）/TNF-相关活化诱导的细胞因子（TRANCE）/NF-κ B受体活化剂配体（RANKL）”作为膜相关因子。破骨细胞前体细胞具有RANK（TNF受体家族成员），通过与成骨细胞/基质细胞的细胞间相互作用识别ODF/OPGL/TRANCE/RANKL，并在巨噬细胞集落刺激因子存在下分化为破骨细胞。成熟破骨细胞也表达RANK，其骨吸收活性也由成骨细胞/基质细胞所具有的ODF/OPGL/TRANCE/RANKL诱导。骨保护素（OPG）/破骨细胞生成抑制因子（OCIF）/TNF受体样分子1（TR 1）是ODF/OPGL/TRANCE/RANKL的可溶性诱饵受体，通过RANK介导的信号传导系统激活NF-kB和c-Jun N-末端激酶似乎参与破骨细胞的分化和激活，（C）1999 Academic Press。
Osteoclasts, the multinucleated giant cells that resorb bone, develop from monocyte-macrophage lineage cells. Osteoblasts or bone marrow stromal cells have been suggested to be involved in osteoclastic bone resorption, The recent discovery of new members of the tumor necrosis factor (TNF) receptor-ligand family has elucidated the precise mechanism by which osteoblasts/stromal cells regulate osteoclast differentiation and function. Osteoblasts/stromal cells express a new member of the TNF-Ligand family "osteoclast differentiation factor(ODF)/osteoprotegerin ligand (OPGL)/TNF-related activation-induced cytokine (TRANCE)/receptor activator of NF-kB ligand (RANKL)" as a membrane associated factor. Osteoclast precursors which possess RANK, a TNF receptor family member, recognize ODF/OPGL/TRANCE/RANKL through cell-to-cell interaction with osteoblasts/stromal cells, and differentiate into osteoclasts in the presence of macrophage colony-stimulating factor. Mature osteo clasts also express RANK, and their bone-resorbing activity is also induced by ODF/OPGL/TRANCE/RANKL which osteoblasts/stromal cells possess. Osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF)/TNF receptor-like molecule 1 (TR1) is a soluble decoy receptor for ODF/OPGL/TRANCE/RANKL, Activation of NF-kB and c-Jun N-terminal kinase through the RANK-mediated signaling system appears to be involved in differentiation and activation of osteoclasts, (C) 1999 Academic Press.