Commentary: IL-4 and IL-13 receptors and signaling.
Commentary: IL-4 and IL-13 receptors and signaling.
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DOI：
10.1016/j.cyto.2015.05.023
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发表时间：
2015-09
期刊：
影响因子：
3.8
通讯作者：
Heller NM
中科院分区：
文献类型：
--
作者：
McCormick SM;Heller NM
白细胞介素（IL）-4和IL-13大约在30年前被发现，并立即与过敏和特应性疾病联系在一起。从那时起，IL-4和IL-13及其受体在正常妊娠、胎儿发育、神经功能以及癌症和纤维化的发病机制中的新作用已被认识。研究IL-4/-13及其受体揭示了细胞因子生物学的重要线索，并导致许多实验疗法的发展。在这里，我们的目标是突出新的发现，并巩固在IL-4和IL-13的结构，受体调控，信号和实验治疗领域的概念。
Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development, neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and lead to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.