Exploring risk factors for follicular lymphoma.
Exploring risk factors for follicular lymphoma.
复制标题
DOI：
10.1155/2012/626035
复制
发表时间：
2012-01-01
影响因子：
--
通讯作者：
Flowers, Christopher R
中科院分区：
文献类型：
--
作者：
Ambinder, Alexander J;Shenoy, Pareen J;Flowers, Christopher R
滤泡性淋巴瘤 (FL) 是一种生发中心 B 细胞的惰性恶性肿瘤，不同种族和地理区域的发病率不同。非霍奇金淋巴瘤亚型分类的改进为探索环境暴露与 FL 发病率之间的关联提供了机会。我们的论文发现，西方生活方式的各个方面，包括久坐的生活方式、肥胖以及富含肉类和牛奶的饮食，与 FL 风险增加有关。富含水果和蔬菜、多不饱和脂肪酸、维生素 D 和某些抗氧化剂的饮食与 FL 风险呈负相关。干燥综合征、流感疫苗接种和心脏病病史可能与 FL 发病有关。 FL 与接触杀虫剂、工业溶剂、染发剂和酒精/烟草之间的关联并不一致。遗传风险因素包括 MHC II 基因座 6p21.32 区域的变异、DNA 修复基因 XRCC3 的多态性以及具有某些维生素 D 受体多态性的个体的紫外线暴露。增加我们对 FL 风险因素的了解必须涉及整合遗传学和暴露的流行病学研究，以便检查风险因素以及基因与环境之间的相互作用。
Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells with varied incidence across racial groups and geographic regions. Improvements in the classification of non-Hodgkin lymphoma subtypes provide an opportunity to explore associations between environmental exposures and FL incidence. Our paper found that aspects of Western lifestyle including sedentary lifestyle, obesity, and diets high in meat and milk are associated with an increased risk of FL. Diets rich in fruits and vegetables, polyunsaturated fatty acids, vitamin D, and certain antioxidants are inversely associated with FL risk. A medical history of Sjogren's syndrome, influenza vaccination, and heart disease may be associated with FL incidence. Associations between FL and exposure to pesticides, industrial solvents, hair dyes, and alcohol/tobacco were inconsistent. Genetic risk factors include variants at the 6p21.32 region of the MHC II locus, polymorphisms of the DNA repair gene XRCC3, and UV exposure in individuals with certain polymorphisms of the vitamin D receptor. Increasing our understanding of risk factors for FL must involve integrating epidemiological studies of genetics and exposures to allow for the examination of risk factors and interactions between genes and environment.