Physical activity mitigates adverse effect of metabolic syndrome on vessels and brain.
Physical activity mitigates adverse effect of metabolic syndrome on vessels and brain.
复制标题
DOI：
10.1007/s11682-018-9830-3
复制
发表时间：
2018-12
影响因子：
3.2
通讯作者：
Tanaka H
中科院分区：
文献类型：
--
作者：
Pasha EP;Birdsill AC;Oleson S;Haley AP;Tanaka H
代谢综合征(METS)对血管系统和大脑白质(CWM)的完整性造成不利影响。动脉硬化与CWM完整性降低有关。体力活动(PA)可以改善蛋氨酸的成分，从而影响动脉硬化和CWM的完整性。我们的目的是确定PA在减轻蛋氨酸对动脉僵硬和CWM完整性的不利影响方面的作用。采用横断面研究设计，研究对象为66名40~62岁的中年人，包括18名久坐不动的蛋氨酸(SED METS)、21名体力活动的METS和27名不存在METS危险因素的健康个体。颈动脉硬度通过同时进行超声和眼压测量来评估。使用扩散张量成像(DTI)通过分数各向异性(FA)和平均扩散系数(MD)测量CWM的完整性。活动期METS患者颈动脉β硬度指数低于SED METS患者，但与健康对照组无差异(6.6±1.5、7.7±2.1和5.6±1.6au，p=0.001)。活动期METS受试者的CWM完整性显著高于SED METS受试者，但在统计上与健康对照组相比，内囊前肢、胼胝体压部、钩状束和放射冠上的CWM完整性相同(均P<；0.05)。与久坐不动的同龄人相比，习惯性进行PA的中年METS患者的动脉僵硬程度较低，CWM完整性较好，这表明PA可能有效地减轻中年时METS对血管和大脑的不利影响。
Metabolic syndrome (MetS) adversely affects the vasculature and cerebral white matter (CWM) integrity. Arterial stiffening has been associated with diminished CWM integrity. Physical activity (PA) can ameliorate components of MetS and subsequently affect arterial stiffening and CWM integrity. Our aim was to determine the role of PA on mitigating the adverse influence of MetS on arterial stiffness and CWM integrity. In a cross-sectional study design, sixty-six middle-aged adults (40–62 years) composed of 18 sedentary MetS (Sed MetS), 21 physically active MetS (Active MetS), and 27 healthy individuals absent of MetS risk factors were studied. Carotid artery stiffness was assessed via simultaneous ultrasound and tonometry. CWM integrity was measured using diffusion tensor imaging (DTI) through metrics of fractional anisotropy (FA) and mean diffusivity (MD). Carotid β-stiffness index in Active MetS was lower than Sed MetS but was not different from Healthy controls (6.6±1.5, 7.7±2.1, and 5.6±1.6 au, p=0.001). CWM integrity was significantly greater in Active MetS subjects compared to Sed MetS subjects but statistically equal to Healthy controls in the anterior limb of the internal capsule, and splenium of the corpus callosum, uncinate fasciculus, and superior corona radiata (all p<0.05). Middle-aged individuals with MetS who habitually perform PA demonstrated lower arterial stiffness and more favorable CWM integrity than their sedentary peers, indicating that PA may be effective in mitigating the adverse effects of MetS on the vasculature and brain at midlife.