INVESTIGATING THE OPTIMAL INITIATION TIME OF ULTRASOUND THERAPY FOR PERIPHERAL NERVE REGENERATION AFTER AXONOTMESIS IN RATS
INVESTIGATING THE OPTIMAL INITIATION TIME OF ULTRASOUND THERAPY FOR PERIPHERAL NERVE REGENERATION AFTER AXONOTMESIS IN RATS
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DOI：
10.1016/j.ultrasmedbio.2021.09.023
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发表时间：
2021-12-23
影响因子：
2.9
通讯作者：
Kuroki, Hiroshi
中科院分区：
文献类型：
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作者：
Kawai, Hideki;Ito, Akira;Kuroki, Hiroshi
本研究旨在确定轴突切断后周围神经再生超声 (US) 治疗的最佳开始时间。将 36 只坐骨神经挤压损伤大鼠分为四组，分别在损伤后 1、7 或 14 天开始接受 US 照射，或接受 4 周的假刺激。每周进行运动功能分析；然而，美国治疗并没有显着改善。伤后4周，伤后1天开始US照射组的复合肌肉动作电位振幅值较假刺激组有显着改善。此外，1天组的髓鞘厚度显着大于其他组。这些结果表明，周围神经损伤后 1 天开始的超声治疗可促进最大限度的再生。 (C) 2021 年世界医学与生物学超声联合会。版权所有。
This study was aimed at identifying the optimal initiation time of ultrasound (US) therapy for peripheral nerve regeneration after axonotmesis. Thirty-six rats with sciatic nerve crush injury were divided into four groups that received US irradiation initiated 1, 7 or 14 d after injury, or sham stimulation for 4 wk. Motor function analysis was conducted weekly; however, there was no significant improvement attributed to US treatment. Four weeks after injury, compound muscle action potential amplitude values of the group in which US irradiation was initiated 1 d after the injury exhibited significant improvement compared with the sham stimulation group. In addition, myelin sheath thick-ness was significantly greater in the 1-d group than in other groups. These results indicate that US treatment initiated 1 d after peripheral nerve injury promotes maximum regeneration. (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.