Prognostic factors in intraoral squamous cell carcinoma: The influence of histologic grade
Prognostic factors in intraoral squamous cell carcinoma: The influence of histologic grade
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DOI：
10.1016/j.joms.2005.07.011
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发表时间：
2005-11-01
影响因子：
1.9
通讯作者：
Holmgren, E
中科院分区：
文献类型：
--
作者：
Kademani, D;Bell, RB;Holmgren, E
目的：这项回顾性研究的目的是回顾在单一机构接受初次手术切除并辅以或不辅以辅助放疗或化放疗的口腔鳞状细胞癌患者的结果，并确定影响生存和局部控制的因素。 患者和方法：从 Legacy Emanuel 医院和健康中心的癌症中鉴定出 1993 年至 2003 年在单一机构治疗的 233 例口腔鳞状细胞癌患者的记录。注册表（俄勒冈州波特兰）。所有接受手术切除作为主要治疗方式的患者均纳入该研究）。患有不可切除疾病、远处转移和随访数据不足的患者被排除在研究之外。手术切缘阳性、组织学分级高、侵袭性生物学行为或疾病处于晚期的患者接受辅助放疗或放化疗。收集的数据包括年龄、性别、种族、肿瘤部位、边缘状态、分级、TNM 分期、癌症治疗和癌症状态。对数据进行统计分析，试图确定局部控制和无病生存的预测因子。计算每个变量的描述性统计数据，并使用 Kaplan-Meier 方法计算生存率。使用 Cox 比例风险模型分析预后因素。 结果：215 名患者，其中 1.19 名男性 (55%) 和 123 名女性 (52%)，诊断时平均年龄为 66 岁 (SD +/- 14)，符合纳入 Stud 的标准。肿瘤平均大小为 23.5 毫米 (SD +/- 14.1)。总体 5 年生存率为 56%，5 年无病生存率为 58%。分期和级别被确定为对生存具有统计显着影响（P = 0.014；似然比卡方 = 10.7，3 个自由度；P = 0.026；似然比卡方 = 5，1 个自由度）。年龄、性别、种族、肿瘤部位或阳性切缘均未显示 7 对生存有统计学显着影响 (P >.05)。结论：本研究强调了分级和分期作为预测口腔鳞状细胞癌患者生存的独立因素的重要性。 (c) 2005 年美国口腔颌面外科医师协会。
Purpose: The purpose of this retrospective study was to review the outcome of patients with oral cavity squamous cell carcinoma treated at a single institution by primary surgical resection with or without adjuvant radiotherapy or chemoradiotherapy and to identify factors affecting survival and locoregional control.Patients and Methods: The records of 233 patients with oral cavity squamous cell carcinoma treated at a single institution from 1993 to 2003 were identified from the Legacy Emanuel Hospital and Health Center's cancer registry (Portland, OR). All patients undergoing surgical resection as a primary treatment modality were included in the stud),. Patients with nonresectable disease, distant metastasis, and those with inadequate follow-up data were excluded from the study. Patients with positive surgical margins, high-grade histology, aggressive biologic behavior, or advanced staged disease underwent adjuvant radiotherapy or chemoradiotherapy. The data collected included age, gender, race, tumor site, margin status, grade, TNM stage, cancer therapies, and cancer status. Data were statistically analyzed in an attempt to identify predictors of locoregional control and disease-free survival. Descriptive statistics were calculated for each variable and survival was calculated using the Kaplan-Meier method. Prognostic factors were analyzed using the Cox proportional hazard model.Results: Two hundred fifteen patients consisting of 1.19 men (55%) and 123 females (52%), with an average age at diagnosis of 66 years (SD +/- 14), met the criteria for inclusion in the Stud),. Average tumor size was 23.5 mm (SD +/- 14.1). Overall 5-year survival was 56% and disease-free survival at 5 years was 58%. Stage and grade were identified as having a statistically significant effect on survival (P =.014; likelihood ratio chi-square = 10.7, 3 degrees of freedom; and P =.026; likelihood ratio chi-square = 5, 1 degree of freedom, respectively). Neither age, gender, race, tumor site, nor positive margins showed 7 a statistically significant effect on Survival (P >.05).Conclusion: This Study highlights the importance of grade and stage as independent factors in predicting survival in patients with oral squamous cell carcinoma. (c) 2005 American Association of Oral and Maxillofacial Surgeons.