TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE
TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE
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DOI：
10.1099/0022-1317-73-8-1891
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发表时间：
1992-08-01
影响因子：
3.8
通讯作者：
WELLS, GAH
中科院分区：
文献类型：
--
作者：
FRASER, H;BRUCE, ME;WELLS, GAH
从4例牛海绵状脑病（BSE）传播给小鼠，在注射后265至700天的潜伏期后，100%的受体动物出现神经系统疾病。四个病例的结果非常相似。有重大差异的潜伏期之间的四个近交系的小鼠测试，甚至之间的菌株相同的Sinc基因型，Sinc杂合子小鼠的潜伏期远长于那些为任何近交系。从自然瘙痒症的情况下，传输不同的两个重要方面：有相同的Sinc基因型的小鼠品系之间的潜伏期没有差异，和杂合子之间的Sinc纯合子亲本菌株。空泡变性在感染羊瘙痒病的小鼠脑中的分布也与感染BSE分离株的小鼠不同。福尔马林固定的BSE脑也实现了传播。这些结果表明，在BSE病例中，同一菌株的病原体引起疾病，BSE与羊瘙痒症的关系尚不清楚。
Transmission from four cases of bovine spongiform encephalopathy (BSE) to mice resulted in neurological disease in 100% of recipient animals, after incubation periods of between 265 and 700 days post-injection. The results from the four cases were very similar to one another. There were major differences in the incubation period between the four inbred strains of mice tested, and even between strains of the same Sinc genotype, and the incubation periods of Sinc heterozygote mice were much longer than those for any of the inbred strains. Transmission from a case of natural scrapie differed in two important respects: there were no differences in the incubation period between mouse strains of the same Sinc genotype, and that of the heterozygotes was between those of the Sinc homozygotic parental strains. The distribution of vacuolar degeneration in the brains of mice infected with scrapie also differed from those infected with the BSE isolates. Transmission was also achieved from formol-fixed BSE brain. These results show that the same strain of agent caused disease in the BSE cases, and that the relationship of BSE to scrapie in sheep is unclear.