A review of the hypoglycemic effects of five commonly used herbal food supplements.
A review of the hypoglycemic effects of five commonly used herbal food supplements.
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DOI：
10.2174/2212798411204010050
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发表时间：
2012-04-01
影响因子：
--
通讯作者：
Deng R
中科院分区：
文献类型：
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作者：
Deng R
高血压是与前驱糖尿病和糖尿病相关的病理状况。糖尿病前期和糖尿病的发病率正在增加，给全球的医疗保健带来了巨大的负担。糖尿病前期和糖尿病患者患心血管疾病和其他并发症的风险显著增加。目前，高血糖症的管理包括药物干预、体育锻炼、生活方式和饮食的改变。食物补充剂已日益成为预防或治疗高血糖症的有吸引力的替代品，特别是对于轻度高血糖症的受试者。本文综述了余甘子、胡芦巴、绿色茶、苦瓜和肉桂等5种常用的具有降血糖作用的食品补充剂的专利和专利申请及其相关文献。来自人类临床研究的数据并不支持所有五种补充剂都能控制高血糖的建议。胡芦巴和含余甘子的复合补充剂在降低糖尿病患者的空腹血糖（FBS）或糖化血红蛋白（HbA1c）水平方面表现出最大的一致性。肉桂和苦瓜的降血糖作用在大多数试验中得到证实，但也有一些例外。然而，绿色茶在降低FBS或HbA1c水平方面的益处有限，不应推荐用于控制高血糖症。在相当数量的临床研究中注意到某些局限性，包括样本量小、实验设计差以及参与者人群、制备形式、每日剂量和治疗持续时间的相当大的变化。未来的研究需要更明确的参与者、标准化的准备和剂量以及改进的试验设计和规模。
Hyperglycemia is a pathological condition associated with prediabetes and diabetes. The incidence of prediabetes and diabetes is increasing and imposes great burden on healthcare worldwide. Patients with prediabetes and diabetes have significantly increased risk for cardiovascular diseases and other complications. Currently, management of hyperglycemia includes pharmacological interventions, physical exercise, and change of life style and diet. Food supplements have increasingly become attractive alternatives to prevent or treat hyperglycemia, especially for subjects with mild hyperglycemia. This review summarized current patents and patent applications with relevant literature on five commonly used food supplements with claims of hypoglycemic effects, including emblica officinalis (gooseberry), fenugreek, green tea, momordica charantia (bitter melon) and cinnamon. The data from human clinical studies did not support a recommendation for all five supplements to manage hyperglycemia. Fenugreek and composite supplements containing emblica officinalis showed the most consistency in lowering fasting blood sugar (FBS) or glycated hemoglobin (HbA1c) levels in diabetic patients. The hypoglycemic effects of cinnamon and momordica charantia were demonstrated in most of the trials with some exceptions. However, green tea exhibited limited benefits in reducing FBS or HbA1c levels and should not be recommended for managing hyperglycemia. Certain limitations are noticed in a considerable number of clinical studies including small sample size, poor experimental design and considerable variations in participant population, preparation format, daily dose, and treatment duration. Future studies with more defined participants, standardized preparation and dose, and improved trial design and size are warranted.