Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease.
Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease.
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DOI：
10.1155/2011/124256
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发表时间：
2011
影响因子：
1.5
通讯作者：
Aigner L
中科院分区：
文献类型：
--
作者：
Kandasamy M;Reilmann R;Winkler J;Bogdahn U;Aigner L
神经干细胞具有再生能力，可以在成年大脑中产生新的功能神经元，这表明损伤或疾病后内源性神经元替代的可能性。亨廷顿病(HD)是一种神经退行性疾病，以基底节神经元丢失为特征，导致运动、认知和心理障碍。显然，为了利用神经干细胞生态位作为HD修复策略的治疗概念，了解在这种神经退行性疾病条件下神经干细胞生态位的细胞和分子组成是很重要的。本文主要讨论了目前对成年脑内海马神经干细胞生态位调节的认识，以及在HD的情况下，这种调节可能通过什么机制受到损害。
The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.