The emerging landscape of circular RNA in cardiovascular diseases.
The emerging landscape of circular RNA in cardiovascular diseases.
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DOI：
10.1016/j.yjmcc.2018.08.012
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发表时间：
2018-09
影响因子：
5
通讯作者：
Meng-yuan Zhou;Jin-Ming Yang;X. Xiong
中科院分区：
文献类型：
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作者：
Meng-yuan Zhou;Jin-Ming Yang;X. Xiong
环状RNA（circRNA）作为一类新型的内源性转录本，已成为RNA生物学领域的新研究热点。 circRNA主要由外显子或内含子通过多种机制产生，并且大多数circRNA在不同物种中是稳定且保守的。最近的研究表明，circRNA 可以充当 miRNA 海绵、蛋白质的结合伴侣、转录调节因子，甚至可以翻译成蛋白质。越来越多的证据表明，circRNA在细胞增殖、凋亡和衰老等多种生物过程中发挥着重要作用，并可能作为各种心血管疾病的潜在诊断生物标志物或治疗靶点。在这里，我们回顾了circRNA的生物发生、特性和生物学功能，并总结了它们在心血管疾病中的作用。
Circular RNAs (circRNAs), a large novel type of endogenous transcripts, have become a new research hotspot in the field of RNA biology. CircRNAs are mainly generated from exons or introns via multiple mechanisms, and the majority of circRNAs are stable and conserved across different species. Recent studies have revealed that circRNAs can function as miRNA sponges, binding partners of proteins, regulators of transcription, or can even be translated into proteins. Growing evidence has demonstrated that circRNAs play important roles in a wide variety of biological processes such as cell proliferation, apoptosis and senescence, and may serve as potential diagnostic biomarkers or therapeutic targets for various cardiovascular diseases. Here, we review the biogenesis, properties and biological function of circRNAs, and summarize their roles in cardiovascular disorders.