Airway mir-155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections
Airway mir-155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections
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DOI：
10.1371/journal.pone.0233352
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发表时间：
2020-05-22
期刊：
影响因子：
3.7
通讯作者：
Nino, Gustavo
中科院分区：
文献类型：
--
作者：
Arroyo, Maria;Salka, Kyle;Nino, Gustavo
micrornas （miRs）控制基因表达和免疫系统和抗病毒反应的发展。MiR-155是一种进化上保守的分子，在不同细胞系统的病毒感染过程中始终被诱导。值得注意的是，miR-155在病毒性呼吸道感染中的作用仍然是一个未解决的悖论。尽管对宿主抗病毒TH1免疫至关重要，但miR-155也可能通过增强过敏性TH2反应和nfkb介导的炎症来促进呼吸系统疾病。本研究的中心目标是确定在幼儿自然发生的病毒性呼吸道感染过程中，气道miR-155的产生与TH1、TH2和促炎细胞因子反应的关系。方法测定归一化后儿童鼻气道miR-155水平及鼻腔ifn - γ、tnf - α、IL-1 β、IL-13、IL-4蛋白水平(
BackgroundMicroRNAs (miRs) control gene expression and the development of the immune system and antiviral responses. MiR-155 is an evolutionarily-conserved molecule consistently induced during viral infections in different cell systems. Notably, there is still an unresolved paradox for the role of miR-155 during viral respiratory infections. Despite being essential for host antiviral TH1 immunity, miR-155 may also contribute to respiratory disease by enhancing allergic TH2 responses and NFkB-mediated inflammation. The central goal of this study was to define how airway miR-155 production is related to TH1, TH2, and proinflammatory cytokine responses during naturally occurring viral respiratory infections in young children.MethodsNormalized nasal airway levels of miR-155 and nasal protein levels of IFN-gamma, TNF-alpha, IL-1 beta, IL-13, IL-4 were quantified in young children (