Health-related quality of life among patients cured by surgery for esophageal cancer
Health-related quality of life among patients cured by surgery for esophageal cancer
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DOI：
10.1002/cncr.22833
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发表时间：
2007-08-01
期刊：
影响因子：
6.2
通讯作者：
Blazeby, Jane M.
中科院分区：
文献类型：
--
作者：
Lagergren, Pernilla;Avery, Kerry N. L.;Blazeby, Jane M.
背景。关于癌症食管切除术幸存者的长期健康相关生活质量 (HRQL) 知之甚少。方法。患者在手术前连续完成了经过欧洲癌症研究与治疗组织验证的一般生活质量问卷 (QLQ-C30) 和食管特异性模块 (QLQ-OES18)，并在手术后定期完成至少 3 年。计算具有 95% 置信区间的平均分数。配对数据的学生 t 检验用于确定基线和 3 年 HRQL 分数之间的差异，其中分数差异 >= 5 分。结果。在 90 名接受手术的患者中，47 名患者 (52%) 存活时间≥ 3 年。在该组中，通过 3 年评估，HRQL 的大部分方面恢复到术前水平，但身体功能、呼吸困难、腹泻和反流的评分显着低于基线时 (P
Background. Little is known regarding the long-term, health-related quality of life (HRQL) of survivors of esophagectomy for cancer.Methods. Consecutive patients completed the validated European Organization for Research and Treatment of Cancer general quality-of life-questionnaire (QLQ-C30) and the esophageal-specific module (QLQ-OES18) before surgery and regularly thereafter for at least 3 years. Mean scores with 95% confidence intervals were calculated. The Student t test for paired data was used to determine differences between baseline and 3-year HRQL scores in which scores differed by >= 5 points.Results. Of 90 patients who underwent surgery, 47 patients (52%) survived for >= 3 years. In this group, most aspects of HRQL recovered to preoperative levels by the 3-year assessment, except that scores for physical function, breathlessness, diarrhea, and reflux were significantly worse than at baseline (P