The aluminium-[(18)F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.

The aluminium-[(18)F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.
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DOI:
10.1186/s41181-021-00141-0
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发表时间:
2021-08-26
影响因子:
4.6
通讯作者:
Allott L
Allott L
中科院分区:
其他
文献类型:
--
作者:
Archibald SJ;Allott L

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[18F]氟化铝 ([18F]AlF) 放射性标记方法将氟 18 有利的衰变特性与金属放射化学的便利性和熟悉性相结合,并已用于平行镓 68 放射性药物的开发。因此,[18F]AlF方法在临床放射性药物的开发中很受欢迎并广泛实施。在这篇综述中,我们了解了基于 [18F]AlF 的技术的现状,并反思了其对核医学的影响,并对这种独特的放射性标记方法的未来提出了我们的看法。
The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.
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