Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease
Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease
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DOI：
10.1002/mds.20493
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发表时间：
2005-08-01
影响因子：
8.6
通讯作者：
Leenders, KL
中科院分区：
文献类型：
--
作者：
Klein, RC;de Jong, BM;Leenders, KL
区分进行性核上性麻痹 (PSP) 和帕金森病 (PD) 可能很困难，尤其是在疾病的早期阶段。正电子发射断层扫描可能提供一种进行这种区分的工具。为了确定脑葡萄糖代谢空间分布的关键特征，将 10 名可能或可能患有 PSP 的患者的 F-18-氟脱氧葡萄糖 (FDG) 测量值与 9 名 PD 患者的测量值直接进行比较。该分析是通过统计参数映射完成的。在全脑摄取正常化后，在 PSP 中，前扣带回尾部（运动）部分 FDG 的相对摄取减少（布罗德曼区 BA 24；P < 0.05，针对多重比较进行校正）。在较低的阈值下，背侧内脑出现额外的减少。在PD中，在纹状外视觉、颞腹外侧、顶叶后部和眶额区观察到相对代谢低下。只有右侧梭状回和外侧纹状视觉皮层的减少达到了统计学显着性。我们的结论是，尤其是内侧额叶代谢的减少可能是区分 PSP 和 PD 的一个有价值的诊断影像参数。对于 PD，枕颞 FDG 减少与易产生幻觉之间可能存在关联。 (c) 2005 年运动障碍协会。
The differentiation between progressive supranuclear palsy (PSP) and Parkinson's disease (PD) may be difficult, especially in the early stages of disease. Positron emission tomography potentially provides a tool for making such a distinction. To identify key features in the spatial distributions of cerebral glucose metabolism, F-18-fluorodeoxyglucose (FDG) measurements of 10 patients with probable or possible PSP were directly compared with those of 9 PD patients. This analysis was done with statistic parametric mapping. After normalization of global brain uptake, in PSP, relative uptake of FDG was reduced in the caudal (motor) part of the anterior cingulate gyrus (Brodmann's area BA 24; P < 0.05, corrected for multiple comparisons). At a lower threshold, an additional decrease was present in the dorsal inesencephalon. In PD, relative hypometabolism was seen in extrastriate visual, ventrolateral temporal, posterior parietal, and orbitofrontal regions. Only reduction in the right fusiform gyrus and the lateral extrastriate visual cortex reached statistical significance. We concluded that particularly the reduction of medial frontal metabolism may be a valuable diagnostic imaging parameter in distinguishing PSP from PD. For PD, a possible association between occipitoternporal FDG decrease and vulnerability to hallucinations is suggested. (c) 2005 Movement Disorder Society.