The rhythmicity of cells of the medial septum diagonal band of Broca in the awake freely moving rat: relationships with behaviour and hippocampal theta
The rhythmicity of cells of the medial septum diagonal band of Broca in the awake freely moving rat: relationships with behaviour and hippocampal theta
复制标题
DOI：
10.1046/j.1460-9568.1998.00026.x
复制
发表时间：
1998-02-01
影响因子：
3.4
通讯作者：
O'Keefe, J
中科院分区：
文献类型：
--
作者：
King, C;Recce, M;O'Keefe, J
慢性细胞外记录是从执行简单行为任务的大鼠的内侧隔膜和布罗卡对角带的细胞中获得的。研究人员发现，这些细胞表现出多种不同程度的与海马θ节律相锁的爆发模式。在锁相细胞中，没有发现优先相位的系统分布，并且这些细胞被证明可以长时间维持其优先相位。将细胞分为表现出动作电位复极相扩大迹象的细胞（“变形”：假定的胆碱能）和没有的细胞（“未变形”：假定的 GABA 能）。未感染的细胞倾向于有节奏地发射，而感染的细胞大多以不规则的方式发射，尽管仍然与海马θ显着锁相。在这两个群体中，锁相细胞都没有表现出其优先相位的任何一致分布。百分之六十五的有节奏的爆发细胞显示出爆发频率与动物的奔跑速度之间存在显着相关性。仅当老鼠朝特定方向奔跑时，五个细胞才会表现出有节奏的活动。这些结果对间隔海马功能模型以及可变间隔节律性对海马θ节律产生的影响具有影响。
Chronic extracellular recordings were obtained from cells of the medial septum and diagonal band of Broca in rats performing a simple behavioural task. The cells were found to display a variety of bursting patterns phase-locked to hippocampal theta rhythm to a greater or lesser degree. Among phase-locked cells, no systematic distribution in preferential phase could be found, and these cells were shown to maintain their preferential phase for extended periods. Cells were classified into those which showed signs of a broadening of the repolarization phase of their action potential ('inflected': putative cholinergic) and those without ('non-inflected': putative GABAergic). Non-inflected cells tended to fire rhythmic bursts while inflected cells mostly fired in an irregular fashion, although still significantly phase-locked to hippocampal theta. In neither population did the phase-locked cells show any coherent distribution of their preferential phase. Sixty-five per cent of the rhythmically bursting cells showed a significant correlation between the interburst frequency and the animal's running speed. Five cells displayed rhythmic activity only when the rat ran in a specific direction. These results have implications for models of septohippocampal function and the effects of variable septal rhythmicity on the production of hippocampal theta rhythm.