Impact of recipient age in outcome of ABO-incompatible living-donor liver transplantation
Impact of recipient age in outcome of ABO-incompatible living-donor liver transplantation
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DOI：
10.1097/01.tp.0000110295.88926.5c
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发表时间：
2004-02-15
期刊：
影响因子：
6.2
通讯作者：
Tanaka, K
中科院分区：
文献类型：
--
作者：
Egawa, H;Oike, F;Tanaka, K
背景ABO血型不合供者的肝移植存在争议，因为存在由预先形成的抗ABO抗体介导的超急性排斥反应的风险。本研究的目的是评估ABO血型不合的活体供肝行肝移植的结果，并检测并发症发生的危险因素。从1990年6月至2000年2月，66例患者，10个月至55岁（中位数，2岁），接受了68 ABO血型不合的活体肝移植。对抗体滴度和临床病程进行前瞻性随访，随访时间为3 ~ 11年。ABO血型不合、ABO血型相容和ABO血型完全相合移植物的5年生存率分别为59%、76%和80%（P
Background. Transplantation of hepatic grafts from ABO-incompatible donors is controversial because of the risk of hyperacute rejection mediated by preformed anti-ABO antibodies. The aim of the present study was to evaluate the outcome of liver transplants performed with ABO-incompatible living-donor livers and to detect risk factors for development of complications.Methods. From June 1990 to February 2000, 66 patients, 10 months to 55 years old (median, 2 years old), received 68 ABO-incompatible living-donor liver grafts. The antibody titer and clinical course were followed prospectively during a period ranging from 3 to 11 years.Results. The 5-year patient survival was 59%, 76%, and 80% for ABO-incompatible, ABO-compatible, and ABO-identical grafts, respectively (P