Elevated anti-annexin V antibody levels in antiphospholipid syndrome and their involvement in antiphospholipid antibody specificities
Elevated anti-annexin V antibody levels in antiphospholipid syndrome and their involvement in antiphospholipid antibody specificities
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DOI：
10.1309/298h-nlbu-e47g-8pyl
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发表时间：
2000-10-01
影响因子：
3.5
通讯作者：
Triplett, DA
中科院分区：
文献类型：
--
作者：
Ogawa, H;Zhao, DD;Triplett, DA
为阐明膜联蛋白V（ANX）与抗磷脂抗体（阿帕）特异性的关系，我们用两种酶联免疫吸附试验平板（普通平板和γ射线平板）检测了53例抗磷脂综合征（APS）患者的抗ANX抗体（aANX）和抗β（2）-糖蛋白I抗体（a-beta（2）GPI）。自身免疫性APS组aANX IgG阳性结果的发生率显著高于健康对照受试者。然而，我们无法证明感染或药物诱导组的发生率显著更高。我们也没有发现IgM同种型的发病率增加。当比较2个平板时，证实了两种同种型的阳性差异。我们推测，平板表面之间的这些差异归因于ANX抗原性的改变。虽然α-β（2）GPI阳性与临床表现有关，但aANX阳性结果的发生率与临床表现之间没有显著相关性。我们推测aANX不太可能参与APS的发病机制。
To clarify the involvement of annexin V (ANX) in antiphospholipid antibody (APA) specificities, we studied antiANX antibodies (aANX) using 2 kinds of enzyme-linked immunosorbent assay plates (plain and gamma-irradiated) and anti-beta(2)-glycoprotein I antibodies (a-beta(2)GPI) in 53 patients with antiphospholipid syndrome (APS). The incidence of aANX IgG-positive results in the autoimmune APS group was significantly higher than that of healthy control subjects. However we could not demonstrate a significantly higher incidence in the infection- or drug-induced group. Nor could we find an increased incidence of IgM isotype. When the 2 plates were compared, the discrepancies of positivity were demonstrated in both isotypes. We speculated that these discrepancies between the plate surfaces were attributed to the altered antigenicity of ANX. Although positivity of a-beta(2)GPI with clinical manifestations, no significant associations were demonstrated between the incidence of aANX-positive results and clinical manifestations. We inferred that the involvement of aANX in the pathogenic mechanism of APS is unlikely.