Thioredoxin-1 is a Novel and Attractive Therapeutic Approach for Various Diseases Including Cardiovascular Disorders
Thioredoxin-1 is a Novel and Attractive Therapeutic Approach for Various Diseases Including Cardiovascular Disorders
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DOI：
10.2174/187152908786786179
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发表时间：
2008-12-01
影响因子：
--
通讯作者：
Rouis, Mustapha
中科院分区：
文献类型：
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作者：
Billiet, Ludivine;Rouis, Mustapha
细胞还原/氧化（氧化还原）平衡的调节由几种抗氧化剂系统如硫氧还蛋白-1（Trx-1）决定，硫氧还蛋白-1（Trx-1）还原靶蛋白上的二硫化物。此外，细胞内的Trx-1发挥其大部分的抗氧化性能，通过清除活性氧。此外，它作为几种酶的辅因子，并在氧化还原敏感性转录因子的调节中发挥重要作用。几项研究已经报道，Trx-1活性可以通过与维生素D3上调蛋白（VDUP-1）（硫氧还蛋白相互作用蛋白-1也称为Txnip或Trx结合蛋白-2也称为TBP-2）的相互作用来调节。据报道，Trx-1分泌发生在与氧化应激和炎症相关的疾病中。血浆Trx-1水平升高对小鼠各种病理学的有益作用被报道。总之，氧化应激是各种病理学包括心血管疾病的重要因素。因此，通过增加Trx-1的活性来控制氧化还原状态似乎是一种新颖且有吸引力的方法。
The regulation of cellular reduction/oxidation (redox) balance is critically determined by several antioxidant systems such as the thioredoxin-1 (Trx-1) which reduces disulfides on targeted proteins. In addition, intracellular Trx-1 exerts most of its antioxidant properties through scavenging of reactive oxygen species. Moreover, it acts as a cofactor for several enzymes and plays an important role in the regulation of redox-sensitive transcription factors. Several studies have reported that Trx-1 activity can be modulated by the interaction with vitamin D3-upregulated protein (VDUP-1) (also called Txnip for thioredoxin interacting protein-1 or TBP-2 for Trx-binding protein-2). Trx-1 secretion has been reported to occur in conditions associated with oxidative stress and inflammation. Beneficial effects of elevated plasma Trx-1 levels on various pathologies were reported in mice.In conclusion, oxidative stress is an important actor in various pathologies including cardio- and cerebro-vascular diseases. Therefore, controlling the redox status by increasing the activity of Trx-1 seems to be a novel and an attractive approach.