The endothelin system. A new target for therapeutic intervention.
The endothelin system. A new target for therapeutic intervention.
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内皮素系统。
DOI：
10.1161/01.cir.89.3.1320
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发表时间：
1994
期刊：
影响因子：
37.8
通讯作者：
M. Yanagisawa
中科院分区：
文献类型：
--
作者：
M. Yanagisawa
自1988年发现内皮素以来，由于其作为内皮源性血管活性因子的独特特性，引起了广泛的跨学科研究兴趣。事实上，就细胞作用机制而言，内皮素似乎与许多经典的血管收缩物质如血管紧张素II和去甲肾上腺素非常相似。然而，其生物合成和分泌的调节机制的缓慢时间过程更类似于炎性细胞因子的调节机制，使该小肽家族在具有心血管相关性的细胞间介质领域内具有独特的地位。
Since its identification in 1988,1 endothelin has attracted intensive interdisciplinary research interest because of its unique profile as an endothelium-derived vasoactive factor with a powerful and characteristically long-lasting vasopressor activity. Indeed, in terms of cellular mechanisms of action, endothelin appears to be quite similar to many classic vasoconstrictor substances such as angiotensin II and norepinephrine. However, the slow time course of the regulatory mechanisms of its biosynthesis and secretion more resembles that of inflammatory cytokines, giving this family of small peptides a unique position within the realm of intercellular mediators with cardiovascular relevance.
内皮素受体拮抗作用对体内急性环孢菌素毒性具有保护作用。
影响因子：
19.6
作者：
Fogo,A;Hellings,SE;Inagami,T;Kon,V
通讯作者：
Kon,V