STUDIES ON FUNGAL PRODUCTS .13. ISOLATION AND STRUCTURES OF DITHIOSILVATIN AND SILVATHIONE, NOVEL DIOXOPIPERAZINE DERIVATIVES FROM ASPERGILLUS-SILVATICUS
STUDIES ON FUNGAL PRODUCTS .13. ISOLATION AND STRUCTURES OF DITHIOSILVATIN AND SILVATHIONE, NOVEL DIOXOPIPERAZINE DERIVATIVES FROM ASPERGILLUS-SILVATICUS
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DOI：
10.1039/p19870002099
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发表时间：
1987-09-01
期刊：
影响因子：
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通讯作者：
KAWAI, K
中科院分区：
文献类型：
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作者：
KAWAHARA, N;NOZAWA, K;KAWAI, K
二硫西伐汀 (1)（一种桥二硫二氧代哌嗪）和银硫酮 (2)（一种二氧代哌嗪硫酮）从森林曲霉中分离出来。它们的结构是根据化学反应和光谱证据确定的。二硫西伐汀 (1) 是天然存在的桥二硫二氧代哌嗪的一个非常罕见的例子，桥二硫二氧代哌嗪是一类最初由甘氨酸、苯丙氨酸或酪氨酸生物合成的化合物。 Silvathione (2) 是天然二氧代哌嗪硫酮的第二个例子，并且在生物遗传学上是从桥二硫二氧代哌嗪形成三氧代哌嗪的可能的关键中间体。
Dithiosilvatin (1), an epidithiodioxopiperazine, and silvathione (2), a dioxopiperazinethione, were isolated from Aspergillus silvaticus. Their structures were established on the basis of chemical reactions and spectroscopic evidence. Dithiosilvatin (1) is a very rare example of naturally occurring epidithiodioxopiperazines, a class of compounds which appear to be biosynthesized originally from glycine, and phenylalanine or tyrosine. Silvathione (2) is the second example of a natural dioxopiperazinethione and is biogenetically a possible key intermediate in the formation of trioxopiperazine from epidithiodioxopiperazine.