Longitudinal genetic analysis of internalizing and externalizing problem behavior in adopted biologically related and unrelated sibling pairs
Longitudinal genetic analysis of internalizing and externalizing problem behavior in adopted biologically related and unrelated sibling pairs
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DOI：
10.1375/twin.10.1.55
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发表时间：
2007-02-01
影响因子：
0.9
通讯作者：
Verhulst, Frank C.
中科院分区：
文献类型：
--
作者：
Huizink, Anja C.;van den Berg, Mijke P.;Verhulst, Frank C.
为了更好地了解遗传和环境过程是如何参与从青春期早期到成年期问题行为的稳定性和变化的，具有遗传信息样本的研究是重要的。本研究采用平均年龄为12.4岁、15.5岁和26.3岁的被收养者父母报告的内化和外化问题行为数据。在这项收养研究中，被收养的有血缘关系的兄弟姐妹平均共享50%的基因，并在同一家庭环境中长大，而被收养的没有血缘关系的兄弟姐妹只共享他们的家庭环境。随着时间的推移，这些被收养的有血缘关系的（N = 106）和没有血缘关系的兄弟姐妹（N = 230）之间的相似性进行了比较和检验。本研究旨在探讨(1)从青春期早期到成年，内化和外化问题行为在多大程度上是稳定的；(2)相同或不同的遗传和环境因素是否会影响这些问题行为。我们的研究结果表明，这两种内化(从。34到。58)和外化行为v的范围从。47 . to…69)随着时间的推移相当稳定。对于问题行为的内化和外化，研究发现，遗传和共同环境的影响都可以通过一个潜在的共同因素来建模，这解释了从青春期早期到成年期问题行为的差异，并解释了随着时间的推移的稳定性。非共享环境影响的最佳模型是内化行为的Cholesky分解，而非共享环境的特定时间影响则包含在外化行为的最终模型中。
To obtain a better understanding of how genetic and environmental processes are involved in the stability and change in problem behavior from early adolescence into adulthood, studies with genetically informative samples are important. The present study used parent-reported data on internalizing and externalizing problem behavior of adoptees at mean ages 12.4, 15.5 and 26.3. In this adoption study adopted biologically related sibling pairs shared on average 50% of their genes and were brought up in the same family environment, whereas adopted biologically unrelated sibling pairs only shared their family environment. The resemblance between these adopted biologically related (N = 106) and unrelated sibling pairs (N = 230) was compared and examined over time. We aimed to investigate (1) to what extent are internalizing and externalizing problem behavior stable from early adolescence into adulthood, and (2) whether the same or different genetic and environmental factors affect these problem behaviors at the 3 assessments. Our results show that both internalizing (rs ranging from .34 to .58) and externalizing behavior Vs ranging from .47 to .69) were rather stable over time. For internalizing and externalizing problem behavior it was found that both genetic and shared environmental influences could be modeled by an underlying common factor, which explained variance in problem behavior from early adolescence into adulthood and accounted for stability over time. The nonshared environmental influences were best modeled by a Cholesky decomposition for internalizing behavior, whereas a time-specific influence of the nonshared environment was included in the final model of externalizing behavior.