Plasma Osteopontin as a Predictor of Coronary Artery Disease: Association With Echocardiographic Characteristics of Atherosclerosis
Plasma Osteopontin as a Predictor of Coronary Artery Disease: Association With Echocardiographic Characteristics of Atherosclerosis
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DOI：
10.1002/jcla.20378
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Al-Zaky, Manar
中科院分区：
文献类型：
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作者：
Abdel-Azeez, Hala Abdel-Hameed;Al-Zaky, Manar
骨桥蛋白（OPN）是一种骨相关蛋白，存在于动脉粥样硬化斑块中，最显著的是钙化斑块。瓣膜钙化被认为是动脉粥样硬化的一部分，与冠状动脉粥样硬化钙化有关。本研究旨在评价血浆OPN与稳定型心绞痛患者冠状动脉狭窄、二尖瓣环钙化（MAC）和主动脉瓣硬化的存在和程度的相关性。我们研究了120名因缺血性胸痛接受冠状动脉造影的受试者。冠状动脉疾病（CAD）定义为≥ 1支冠状动脉狭窄≥ 50%。超声心动图检测MAC和主动脉瓣硬化。测量所有研究对象的血脂、高敏C反应蛋白（hsCRP）和骨桥蛋白（OPN）。冠心病患者血浆OPN水平高于非冠心病患者（P
Osteopontin (OPN), a bone-related protein, is present within the atherosclerotic plaques, most strikingly in calcified plaques. Valvular calcifications are accepted as a part of the spectrum of atherosclerosis and are associated with atherosclerotic calcification in the coronary arteries. The study aimed to evaluate the association of plasma OPN with the presence and extent of coronary stenosis, mitral annular calcification (MAC), and aortic valve sclerosis in stable angina patients. We studied 120 subjects who underwent coronary angiography because of ischemic chest pain. Coronary artery disease (CAD) was defined as >= 50% stenosis in >= 1 coronary artery. MAC and aortic valve sclerosis were detected by echocardiography. Lipid profile, high sensitive C-reactive protein (hsCRP), and OPN were measured in all studied subjects. Patients with CAD had increased plasma OPN when compared with those without CAD (P