The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes
The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes
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DOI：
10.3177/jnsv.62.249
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发表时间：
2016-08-01
影响因子：
1.6
通讯作者：
Tachibana, Hirofumi
中科院分区：
文献类型：
--
作者：
Yamashita, Mai;Kumazoe, Motofumi;Tachibana, Hirofumi
西方饮食诱导肥胖与高胆固醇血症的风险增加。事实上，肥胖引起的高胆固醇血症与冠心病（CVD）风险增加相关。雄性C57 BL/6 J小鼠分别饲喂普通饲料、高脂高糖饲料（HF/HS）、HF/HS+绿色茶提取物粉饲料（HF/HS + GT）、HF/HS+圣草酚饲料（HF/HS + Eri）或HP/HS+绿色茶提取物粉和圣草酚饲料（HF/HS + GT + Eri）8周。HF/HS + GT + Eri组的体重低于BF/HS组（-8.3%，p
Western diets induce obesity associated with an increased risk of hypercholesterolaemia. Indeed, obesity-induced hypercholesterolaemia is correlated with increased coronary cardiovascular disease (CVD) risk. Male C57BL/6J mice were fed a normal diet, high fat and high-sucrose diet (HF/HS), HF/HS with green tea extract powder diet (HF/HS+GT), HF/HS with eriodictyol diet (HF/HS+Eri), or HP/HS with green tea extract powder and eriodictyol diet (HF/HS + GT +Eri) for 8 wk. Body weight was lower in the HF/HS + GT +Eri group than in the BF/HS group (-8.3%, p