Indocyanine Green: Photosensitizer or Chromophore? Still a Debate
Indocyanine Green: Photosensitizer or Chromophore? Still a Debate
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DOI：
10.2174/0929867321666131218095802
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发表时间：
2014-05-01
影响因子：
4.1
通讯作者：
Frochot, Celine
中科院分区：
文献类型：
--
作者：
Giraudeau, Camille;Moussaron, Albert;Frochot, Celine
吲哚菁绿色（ICG）是第二次世界大战期间开发的一种水溶性阴离子三碳菁染料，于1956年首次批准用于人类临床。ICG的主要特点，使其适用于生物成像应用是其近红外吸收和荧光。尽管ICG主要用于其荧光发射性质，但也假设其可用作光动力治疗应用的光敏剂，当与800-830 nm范围内的波长的光组合使用时在体外和体内引发细胞毒性效应。此外，ICG可用于血管增强光凝治疗的热疗。在本文中，我们收集了所有可用的数据，关于使用ICG的不同治疗。
Indocyanine green (ICG) is a water-soluble anionic tricarbocyanine dye developed during the Second World War that was first approved for clinical use in humans in 1956. The main features of ICG that make it suitable for bio-imaging applications are its near infrared absorption and its fluorescence. Although ICG is mainly used for its fluorescence emission properties, it has also been hypothesized that it can serve as a photosensitizer for photodynamic therapy applications, eliciting cytotoxic effects both in vitro and in vivo when used in combination with light at wavelengths in the region of 800-830 nm. Moreover, ICG can be used for hyperthermia of enhanced-photocoagulation of blood vessels treatment. In this paper we have gathered all the available data concerning the use of ICG for different treatments.