Genome analysis linking recent European and African influenza (H5N1) viruses.
Genome analysis linking recent European and African influenza (H5N1) viruses.
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基因组分析将最近的欧洲和非洲流感（H5N1）病毒联系起来。
DOI：
10.3201/eid1305.070013
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发表时间：
2007-05
影响因子：
11.8
通讯作者：
Capua, Ilaria
中科院分区：
文献类型：
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作者：
Salzberg, Steven L;Kingsford, Carl;Cattoli, Giovanni;Spiro, David J;Janies, Daniel A;Aly, Mona Mehrez;Brown, Ian H;Couacy-Hymann, Emmanuel;De Mia, Gian Mario;Dung, Do Huu;Guercio, Annalisa;Joannis, Tony;Maken Ali, Ali Safar;Osmani, Azizullah;Padalino, Iolanda;Saad, Magdi D;Savic, Vladimir;Sengamalay, Naomi A;Yingst, Samuel;Zaborsky, Jennifer;Zorman-Rojs, Olga;Ghedin, Elodie;Capua, Ilaria
虽然这些病毒相互关联，但与早期爆发的病毒株不同。为了更好地了解高致病性禽流感病毒在其跨大陆传播中的生态学和流行病学，我们对从欧洲、北方和东南亚鸟类中收集的36种最近的甲型H5 N1流感病毒的完整基因组进行了测序和分析。这些序列是亚洲以外第一批完整的流感（H5 N1）病毒基因组，清楚地描绘了目前感染欧洲和非洲野生和家养鸟类的谱系，并显示了这些分离株与影响鸟类和人类的其他毒株之间的关系。分离株分为3个不同的谱系，其中1个包含所有已知的非亚洲分离株。这种新的欧洲-非洲谱系是最近（2006年）在埃及和伊拉克发生的几起致命性人类感染的原因，已至少3次引入欧洲-非洲地区，并已分为3个不同的、独立进化的亚谱系。一个分离株提供的证据表明，这些亚系中有2个最近发生了重组。
Although linked, these viruses are distinct from earlier outbreak strains. To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted.