Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy
Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy
复制标题
射频消融不充分通过自噬促进残留肝细胞癌的增殖
DOI：
10.1016/j.canlet.2018.02.024
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发表时间：
2018-01-01
期刊：
影响因子：
9.7
通讯作者：
Luo, Baoming
中科院分区：
文献类型：
--
作者：
Zhao, Zizhuo;Wu, Jiayi;Luo, Baoming
射频消融（RFA）被认为是治疗肝细胞癌（HCC）的一种潜在治疗方法。然而，不充分的RFA（IRFA）可促进残留肿瘤的快速进展。IRFA诱导的肿瘤促进的潜在机制仍然知之甚少。在本研究中，我们建立了一个皮下异种移植小鼠模型，并通过超声和热成像仪双重监测来监测IRFA的位置和程度。我们首次提供了暴露于IRFA的小鼠中自噬途径激活的证据。我们发现自噬在IRFA后的复发和增殖中起着重要作用，而羟氯喹（HCQ）可以抑制这些作用。我们的研究结果表明，自噬参与了实验性IRFA，抑制自噬可能是一种新的方法，在治疗肝癌局部复发后IRFA在临床上。(C)2018爱思唯尔B.V.保留所有权利。
Radiofrequency ablation (RFA) is considered to be a potentially curative therapy for hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can promote rapid progression of the residual tumor. The mechanisms underlying IRFA-induced tumor promotion remain poorly understood. In the present study, we have established a subcutaneous xenograft mouse model and monitored the location and extent of IRFA by dual monitoring with ultrasonography and a thermal imager. For the first time, we provide evidence of the activation of autophagic pathways in mice exposed to IRFA. We show that autophagy plays an important role in relapse and proliferation after IRFA and that hydroxychloroquine (HCQ) can suppress these effects. Our findings indicate that autophagy is involved in experimental IRFA and that inhibition of autophagy may be a novel approach in the treatment of local recurrences of HCC after IRFA in the clinic. (C) 2018 Elsevier B.V. All rights reserved.